Results 141 to 150 of about 433,281 (311)
c‐Rel–dependent Chk2 signaling regulates the DNA damage response limiting hepatocarcinogenesis
Hepatology, EarlyView., 2022 In response to genotoxic injury, c‐Rel upregulates ATM‐Chk2‐p53 pathway DNA damage proteins to limiting hepatocarcinogenesis. Abstract Background and Aims Hepatocellular carcinoma (HCC) is a leading cause of cancer‐related death. The NF‐κB transcription factor family subunit c‐Rel is typically protumorigenic; however, it has recently been reported as a
Jack Leslie +17 more
wiley +1 more source
Onofre Lovero (1925-2012): Cuando un maestro emprende la gira [PDF]
, 2013 Fos, Carlos
core +2 more sources
Animal Models and Experimental Medicine, EarlyView.This study presents an integrative multi‐omics framework to uncover the molecular mechanisms and potential biomarkers of chronic thromboembolic pulmonary hypertension (CTEPH). Anthropometric and biochemical data were correlated using canonical correlation analysis, revealing key cardiometabolic associations. Single‐cell RNA sequencing identified immune
Xiaopeng Liu +4 more
wiley +1 more source
In Situ Construction of Imidazopyridinium Fluorescent Labels for Bioconjugation
Angewandte Chemie International Edition, EarlyView.Chromophore engineering of isoquinoline aldehydes generates TICT‐based fluorogenic dyes for in situ labeling of diverse (bio)molecules with large Stokes shifts compatible with cell imaging. ABSTRACT Simple, efficient transformations of fluorogenic nature that proceed under biocompatible conditions without the formation of byproducts are of high ...
Dongchen Du +7 more
wiley +1 more source
Cell Death and DiseaseAcquired drug resistance is one of the most common limitations for the clinical response of colon cancer to 5-Fluorouracil (5-FU)-based chemotherapy. The relevant molecular mechanisms might be diversity, but still not be elucidated clearly. In this study,
Yanping Gui +8 more
doaj +1 more source
The Anatomical Record, EarlyView.Abstract A subadult Moschognathus whaitsi from the Eastern Cape Province, South Africa, was scanned using synchrotron radiation X‐ray computed tomography (SRXCT). Its subadult state allowed the cranial bones and teeth to be identified and individually reconstructed in 3D.
Tristen Lafferty +3 more
wiley +1 more source
Morphological variation in atlas and axis of Neotropical spiny rats (Rodentia, Echimyidae)
The Anatomical Record, EarlyView.Abstract The unique morphologies of the first two cervical vertebrae, the atlas and axis, represent a significant innovation in mammalian evolution. These structures support the weight of the head and enable intricate movements of the head and neck.
Thomas Furtado da Silva Netto +3 more
wiley +1 more source
The Anatomical Record, EarlyView.Abstract Neuroanatomical research has progressed considerably in several vertebrate lineages, yet studies of reptilian brain morphology remain markedly underdeveloped. Here we provide the first description of macroscopic brain anatomy and its ontogeny in the viperid Bothrops moojeni, based on a sample of seven individuals.
Paula Araújo +2 more
wiley +1 more source
Cold Spring Harbor Symposia on Quantitative Biology, 1986 I M, Verma +3 more
openaire +2 more sources
The Anatomical Record, EarlyView.Abstract The middle Permian represents a critical interval in therapsid evolution, when gorgonopsians emerged as some of the first specialized apex predators within terrestrial ecosystems. Despite their significance, the early diversification of Gorgonopsia in Gondwana remains poorly understood due to scarcity and fragmentary material.
Zanildo Macungo +5 more
wiley +1 more source