Results 151 to 160 of about 499,874 (389)

Conversion of Transplanted Mature Hepatocytes into Afp+ Reprogrammed Cells for Liver Regeneration After Injury

Advanced Science, EarlyView.
Donor‐derived tdTomato+ mature hepatocytes were FACS‐isolated and transplanted into Fah−/− host mice. During regeneration, these cells convert into proliferative, unipotent Afp+ rHeps. Their plasticity is governed by a PPARγ/AFP‐dependent metabolic switch, segregating into pro‐proliferative Afplow and pro‐survival Afphigh subpopulations.
Ting Fang, Chao Yang, Hua Qiu, Yuan Du, Xicheng Wang, Yuting Li, Mingyang Xu, Changcheng Liu, Xiuhua Li, Na Guo, Jun Shi, Wencheng Zhang, Zhiying He   +12 more
wiley   +1 more source

Spatial memory formation differentially affects c-Fos expression in retrosplenial areas during place avoidance training in rats [PDF]

, 2016
Monika Malinowska, Monika Niewiadomska, M Wesierska   +2 more
openalex   +1 more source

Nanoparticle Immunoadjuvant Complexes Augment Germinal Center Responses to Vaccination

Advanced Science, EarlyView.
Scaffolding IL‐21 on the surface of a self‐assembling nanoparticle immunogen drives improved germinal center and humoral immune responses. These nanoparticle immunoadjuvant complexes (NICs) functionally modulate the germinal center driving improved somatic hypermutation and antibody maturation, suggesting this platform has potential utility as a ...
Nicholas J. Tursi, Colby J. Agostino, Jinwei Huang, Toshitha Kannan, Niklas Laenger, Jennifer Londregan, Katlyn Lederer, Michaela Helble, Nicole Bedanova, Cory Livingston, Ebony N. Gary, Madison McCanna, Marta Tarquis Medina, Rumi Habib, Ignacio Rodriguez Relaño, Ivan Maillard, Ami Patel, David Allman, Andrew Kossenkov, Amelia Escolano, Daniel W. Kulp, David. B. Weiner   +21 more
wiley   +1 more source

Enhancement of capacity of farmer organizations for sustainable irrigation systems in Anuradhapura and Kurunegala districts [PDF]

Over the past decades public investment in major, medium and minor irrigation systems has not yielded the expected results. The solution to the growing water crisis lies in the institutional reform of existing social systems so as to manage the demand ...
Thiruchelvam, S.
core  

Time-Resolved Ultraviolet Observations of the Globular Cluster X-ray Source in NGC 6624: The Shortest Known Period Binary System

, 1997
Using the Faint Object Spectrograph (FOS) aboard the Hubble Space Telescope, we have obtained the first time-resolved spectra of the King et al. ultraviolet-bright counterpart to the 11-minute binary X-ray source in the core of the globular cluster NGC ...
Auriere M., Auriere M., Bruce Margon, Deutsch E. W., Eric W. Deutsch, Homer L., Richard G. Allen, Ronald A. Downes, Scott F. Anderson   +8 more
core   +1 more source

A Non‐Mitophagy Activity of BNIP3L/NIX in Amygdala Glutamatergic Neurons is Essential for Contextual Fear Memory Formation

Advanced Science, EarlyView.
Contextual fear conditioning induces BNIP3L‐dependent mitochondrial fission in glutamatergic neurons of the BLA, independently of mitophagy. Loss of BNIP3L elevates Drp1Ser637 phosphorylation, thereby suppressing mitochondrial fission, compromising ATP production, and attenuating excitatory synaptic transmission.
Xingxian Zhang, Xinlei Mo, Xinyu Zhou, Xiaoliang Liu, Guizhi Li, Songhui Hu, Yangyang Lu, Chenze Zhu, Jinxi Feng, Zhitong Chen, Weiwei Hu, Yihui Cui, Zhong Chen, Xiangnan Zhang   +13 more
wiley   +1 more source

Produção simultânea de -fructofuranosidase e fructo-oligossacarídeos por Penicillium citreonigrum URM 4459 [PDF]

, 2016
O objetivo deste trabalho foi a produção simultânea de -Frutofuranosidase (FFase) e frutooligossacarídeos (FOS) por P. citreonigrum utilizando um planejamento fatorial completo. Para isso, o fungo foi cultivado em meio rico em sacarose (20% p/v) a 150
Gonçalves, Clarisse Salomé Nobre, Nascimento, A. K. C., Porto, A. L. F., Soares, Maria T. C. V., Teixeira, J. A.   +4 more
core  

Two polymorphisms of the FOS oncogene [PDF]

, 1990
M.A. Siewertsen, David F. Barker, D W Cox   +2 more
openalex   +1 more source

Hepatocyte BPGM Induces RET Lactylation and Macrophage Reprogramming to Promote Tumorigenesis in Hepatocellular Carcinoma

Advanced Science, EarlyView.
Mechanistic schematic diagram.BPGM promotes the expression level of RET by increasing the lactylation of RET‐K549 and inhibiting its ubiquitination levels in HCC cells. Furthermore, BPGM in HCC cells could also promote M2 polarization in macrophages through lactate secretion. Both of the mechanisms could promote the progression of HCC. ABSTRACT Aerobic
Jiajia Zhang, Lu Shi, Liangliang Lin, Yang Zhang, Miao Zhang, Lili Wu, Yong Xia, Yaqiong Zhang, Peng Han, Likun Zhuang, Liang Shi   +10 more
wiley   +1 more source

METTL3 drives heart failure by regulating Spp1 and Fos m6A modification in myocardial infarction [PDF]

Haixia Cheng, Le Li, Juying Qian, Yunzeng Zou, J Y, Junbo Ge   +5 more
openalex   +1 more source