Results 91 to 100 of about 29,630 (214)
The Varied Role of Efflux Pumps of the MFS Family in the Interplay of Bacteria with Animal and Plant Cells [PDF]
Efflux pumps represent an important and large group of transporter proteins found in all organisms. The importance of efflux pumps resides in their ability to extrude a wide range of antibiotics, resulting in the emergence of multidrug resistance in many
Barras, Frederic +7 more
core +3 more sources
ABSTRACT Background Targeted antimicrobial therapy for canine otitis externa (OE) represents an opportunity for antimicrobial stewardship. Fosmidomycin selectively inhibits the non‐mevalonate pathway for isoprenoid biosynthesis utilised by canine‐adapted, and not human‐adapted, staphylococci.
Lindsey E. Citron +6 more
wiley +1 more source
: Objective: To evaluate the efficacy of high-dose intravenous fosfomycin for the treatment of urinary tract infections (UTI) caused by KPC carbapenemase-producing Klebsiella pneumoniae (KPC-Kp).
Jorge Rodríguez-Gómez +14 more
doaj +1 more source
Exploring dangerous connections between Klebsiella pneumoniae biofilms and healthcare-associated infections [PDF]
Healthcare-associated infections (HAI) are a huge public health concern,particularly when the etiological agents are multidrug resistant. The ability of bacteria to develop biofilm is a helpful skill, both to persist within hospital units and to ...
Bandeira, Maria +3 more
core +2 more sources
Antimicrobial stressors, that is, bile or mitomycin C, induce enlarged, nucleic acid‐rich bacterial extracellular vesicles in Vibrio cholerae that facilitate horizontal gene transfer in vitro and during intestinal colonisation. The findings provide a detailed comparison of control versus stress‐induced vesicles, identify bile as a host factor shaping ...
Dominik Fleischhacker +6 more
wiley +1 more source
ABSTRACT Introduction Livestock markets are critical hubs within animal trade networks that influence pathogen dissemination at the regional and national scale. Indeed, a 2016 Salmonella serovar Heidelberg outbreak, initially linked to surplus dairy calves at livestock markets, sickened 63 people across 17 states.
Samantha R. Locke +6 more
wiley +1 more source
The Role of Bacillithiol in Gram-Positive Firmicutes [PDF]
Significance: Since the discovery and structural characterization of bacillithiol (BSH), the biochemical functions of BSH-biosynthesis enzymes (BshA/B/C) and BSH-dependent detoxification enzymes (FosB, Bst, GlxA/B) have been explored in Bacillus and ...
Antelmann, Haike +3 more
core +1 more source
ABSTRACT Introduction The emergence of methicillin‐resistant Staphylococcus species (MRS) poses a growing threat to both human and veterinary health. Methods We performed a comparative genomic characterisation of 49 methicillin‐resistant Staphylococcus isolates collected from humans, dogs, and cats in a veterinary hospital from Central Chile.
Daniel Garrido +7 more
wiley +1 more source
The efficacy of fosfomycin is increasingly challenged by emerging resistance mechanisms, primarily involving fosfomycin-modifying enzymes and target (MurA) alterations. This study aimed to elucidate the novel mechanism underlying fosfomycin resistance in
Honghao Huang +10 more
doaj +1 more source
Fosfomycin: A First-Line Oral Therapy for Acute Uncomplicated Cystitis
Fosfomycin is a new agent to Canada approved for the treatment of acute uncomplicated cystitis (AUC) in adult women infected with susceptible isolates of E. coli and Enterococcus faecalis.
George G. Zhanel +2 more
doaj +1 more source

