Results 41 to 50 of about 263,880 (288)
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Peer or Parent: The Role of Adolescent Children of Local Authority Foster Carers [PDF]
, 2023 Rebecca Pratchett
openalex +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
GROOTMOEDERS IN KAYAMANDI SE ERVARING VAN FAMILIEPLEEGSORG
Social Work/Maatskaplike Werk, 2006 Pleegplasings by familie as vorm van substituutsorg, is die vinnigs groeiende kindersorgdiens in die Verenigde State van Amerika (voorts genoem die VSA) as gevolg van ’n afname in geskikte pleegouers (Wilson & Chipunga, 1996:387).
Dora van Rensburg, Sulina Green
doaj +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
How Do People Become Foster Carers in Portugal? The Process of Building the Motivation
Social Sciences, 2019 Act no. 142/2015 highlights the importance of children out-of-home being placed in a family context. However, foster care continues to be an almost absent component in the Portuguese childcare system.
Elisete Diogo, Francisco Branco
doaj +1 more source
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Case Reports in Hematology, 2016 We are reporting a case of a healthy 21-year-old male, with no significant past medical history, who was found to have an incidental nonocclusive deep vein thrombosis in the right internal jugular vein detected on a head MRI previously ordered for work ...
Javier Corral, Geri Villanueva
doaj +1 more source
Colloquium, 2020 The social and political transformation that occurred in Poland following the fall of the communist system has resulted in an intensive development of non-governmental organizations, including those offering services for children and families.
Piotr Kulikowski
doaj +1 more source