Results 211 to 220 of about 145,935 (291)

Optimizing sterile filtration of nanoemulsions through proper choice of prefilter properties

open access: yesBiotechnology Progress, EarlyView.
Abstract Nanoemulsions, with droplet sizes between 20 and 200 nm, have emerged as a promising vaccine adjuvant and drug delivery system, enhancing the solubility of hydrophobic drugs for diverse applications. Sterile filtration of nanoemulsions is particularly challenging due to the similar size between the nanodroplets and the 0.2 μm nominal pore size
Shreya Kapila   +4 more
wiley   +1 more source

Properties governing the transport of organic pollutants through ion-exchange membranes using desalination of complex waste streams in ED [PDF]

open access: yes, 2015
Gaublomme, Dorien   +5 more
core  

Effect of cell retention techniques in Komagataella phaffii lab‐scale continuous processes

open access: yesBiotechnology Progress, EarlyView.
Abstract Perfusion technologies play a growing role in the implementation of continuous processes for biotherapeutics production in mammalian‐based manufacturing. However, their application to alternative production hosts is limited. Cell retention systems are of key importance for the efficiency of perfusion bioreactors.
Marina Y. Linova   +5 more
wiley   +1 more source

Antifouling Lipids from Marine Fungi of the Beibu Gulf. [PDF]

open access: yesMetabolites
Qi M   +8 more
europepmc   +1 more source

Enhancing CHO cell recombinant protein production using a perfusion‐directed host evolution approach

open access: yesBiotechnology Progress, EarlyView.
Abstract Clonally derived cell lines generated from Chinese hamster ovary (CHO) cells encounter numerous stressors when cultured in high‐intensity perfusion bioreactors leading to poor process performance. To circumvent this, the ability of CHO cells to adapt to different culture environments was exploited. Here host cells were selected in the presence
Peter Amaya   +7 more
wiley   +1 more source

A case study showing the role of hydrophobicity variants and other enriched mAb proteoforms on filterability through a virus filter with productivity improvement measures

open access: yesBiotechnology Progress, EarlyView.
Abstract A rapid assessment of manufacturability for drug candidates is crucial for advancing a prospective biotherapeutic from a candidate to a bulk drug substance. A lot‐to‐lot approach to manufacturability is adopted where each biologic batch is assessed for manufacturability as a bulk, unfractionated pool.
Solomon Isu   +6 more
wiley   +1 more source

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