Optimizing sterile filtration of nanoemulsions through proper choice of prefilter properties
Abstract Nanoemulsions, with droplet sizes between 20 and 200 nm, have emerged as a promising vaccine adjuvant and drug delivery system, enhancing the solubility of hydrophobic drugs for diverse applications. Sterile filtration of nanoemulsions is particularly challenging due to the similar size between the nanodroplets and the 0.2 μm nominal pore size
Shreya Kapila +4 more
wiley +1 more source
Effect of Nanobubbles on Ultrafiltration Membrane Performance and Properties of Model Cheese Whey. [PDF]
Akshit F, Bharti SK, Mohan MS.
europepmc +1 more source
Properties governing the transport of organic pollutants through ion-exchange membranes using desalination of complex waste streams in ED [PDF]
Gaublomme, Dorien +5 more
core
Effect of cell retention techniques in Komagataella phaffii lab‐scale continuous processes
Abstract Perfusion technologies play a growing role in the implementation of continuous processes for biotherapeutics production in mammalian‐based manufacturing. However, their application to alternative production hosts is limited. Cell retention systems are of key importance for the efficiency of perfusion bioreactors.
Marina Y. Linova +5 more
wiley +1 more source
Antifouling Lipids from Marine Fungi of the Beibu Gulf. [PDF]
Qi M +8 more
europepmc +1 more source
Enhancing CHO cell recombinant protein production using a perfusion‐directed host evolution approach
Abstract Clonally derived cell lines generated from Chinese hamster ovary (CHO) cells encounter numerous stressors when cultured in high‐intensity perfusion bioreactors leading to poor process performance. To circumvent this, the ability of CHO cells to adapt to different culture environments was exploited. Here host cells were selected in the presence
Peter Amaya +7 more
wiley +1 more source
Ohmic Losses Dominated Electrode Fouling during Long-Term Aluminum Electrocoagulation of Hypersaline and Divalent Cation-Rich Oilfield-Produced Water. [PDF]
Joag S, Kiesewetter J, Chellam S.
europepmc +1 more source
Abstract A rapid assessment of manufacturability for drug candidates is crucial for advancing a prospective biotherapeutic from a candidate to a bulk drug substance. A lot‐to‐lot approach to manufacturability is adopted where each biologic batch is assessed for manufacturability as a bulk, unfractionated pool.
Solomon Isu +6 more
wiley +1 more source

