Results 51 to 60 of about 420,357 (288)

Geotechnological Foundations of Mining Natural-Technogenic Deposits in Donbas

open access: yesJournal of Geology, Geography and Geoecology, 2020
The purpose of this study is to substantiate theoretically and technologically both parameters, formation and recovery schemes to use natural-technogenic and capacity resources of the mined coal deposits with the help of a set of geo-modules providing their activation, extraction, and storage depending on seasonable irregularity of energy consumption ...
Nataliia I. Dereviahina   +2 more
openaire   +2 more sources

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Gemological and Chemical Characterization of Gem-Grade Peridot from Yiqisong, Jilin Province

open access: yesCrystals
Peridot has a long history and is deeply loved by people for its unique olive-green color. The Yiqisong peridot deposit in Jilin Province is a newly discovered peridot deposit that still deserves systematic research.
Jina Li, Yi Zhao, Bo Xu
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

¿Qué desafíos presenta el Sínodo de la Amazonía a la teología? Pensar el problema desde los posibles retos al estatuto epistemológico de la teología

open access: yesFranciscanum, 2021
The challenges that the Synod of the Amazon presents to theology are worked on the horizon of the question of the epistemological status of theology, based on the use of some metaphors used by the texts of the Synod.
Vicente Valenzuela Osorio
doaj   +1 more source

The early Cycladic settlement at Dhaskalio, Keros: preliminary report of the 2008 excavation season [PDF]

open access: yes, 2009
The 2008 excavations on the small island of Dhaskalio opposite Dhaskalio Kavos on the Cycladic island of Keros are reviewed. An account is given of the survey, recording many walls of the early Bronze Age, and of the excavations, continued from the 2007 ...
Brodie, N.   +3 more
core   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Local government interventions for improving the health and wellbeing of tenants in private rented housing: developing initial program theory to inform evaluation in the United Kingdom

open access: yesBMC Public Health
Background Housing is an important wider determinant of health. Private Rented Sector (PRS) housing is generally the worst quality of housing stock across tenures.
Rachael McClatchey   +4 more
doaj   +1 more source

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