Results 131 to 140 of about 4,219,089 (361)

Cellular liquid biopsy provides unique chances for disease monitoring, preclinical model generation and therapy adjustment in rare salivary gland cancer patients

Molecular Oncology, EarlyView.
We quantified and cultured circulating tumor cells (CTCs) of 62 patients with various cancer types and generated CTC‐derived tumoroid models from two salivary gland cancer patients. Cellular liquid biopsy‐derived information enabled molecular genetic assessment of systemic disease heterogeneity and functional testing for therapy selection in both ...
Nataša Stojanović Gužvić, Florian Lüke, Steffi Treitschke, Andrea Coluccio, Martin Hoffmann, Giancarlo Feliciello, Adithi Ravikumar Varadarajan, Xin Lu, Kathrin Weidele, Catherine Botteron, Silvia Materna–Reichelt, Felix Keil, Katja Evert, Florian Weber, Thomas Schamberger, Michael Althammer, Jirka Grosse, Dirk Hellwig, Christian Schulz, Stephan Seitz, Peter Ugocsai, Anke Schlenska‐Lange, Roman Mayr, Ulrich Kaiser, Wolfgang Dietmaier, Bernhard Polzer, Jens Warfsmann, Kamran Honarnejad, Tobias Pukrop, Daniel Heudobler, Christoph A. Klein, Christian Werno   +31 more
wiley   +1 more source

Defense Priorities in the Open-Source AI Debate: A Preliminary Assessment [PDF]

arXiv
A spirited debate is taking place over the regulation of open foundation models: artificial intelligence models whose underlying architectures and parameters are made public and can be inspected, modified, and run by end users. Proposed limits on releasing open foundation models may have significant defense industrial impacts.
arxiv  

Aligning Capital With Mission: Lessons from the Annie E. Casey Foundation's Social Investment Program [PDF]

, 2016
The Annie E. Casey Foundation engaged InSight at Pacific Community Ventures to conduct the first comprehensive third-party evaluation of the SI Program, with research support from the Center for the Advancement of Social Entrepreneurship (CASE) at Duke ...

core  

The Noise of Gravitons

, 2020
We show that when the gravitational field is treated quantum-mechanically, it induces fluctuations -- noise -- in the lengths of the arms of gravitational wave detectors.
Parikh, Maulik, Wilczek, Frank, Zahariade, George   +2 more
core   +1 more source

Targeting rapid TKI‐induced AXL upregulation overcomes adaptive ERK reactivation and exerts antileukemic effects in FLT3/ITD acute myeloid leukemia

Molecular Oncology, EarlyView.
Adaptive ERK reactivation hinders FLT3 tyrosine kinase inhibitor (TKI) treatment in FLT3/ITD acute myeloid leukemia. Here, we report that FLT3 TKI treatment rapidly induces AXL expression and upregulation that is temporally associated with the adaptive ERK reactivation.
Tessa S. Seale, Li Li, J. Kyle Bruner, Melody Chou, Bao Nguyen, Jaesung Seo, Ruiqi Zhu, Mark J. Levis, Christine A. Pratilas, Donald Small   +9 more
wiley   +1 more source

Correction to: Integrated models of care for diabetes and hypertension in low- and middle-income countries (LMICs): Protocol for a systematic review

Systematic Reviews, 2019
Following publication of the original article [1], the author reported that their family name was misspelled.
Jeannine Uwimana Nicol, Anke Rohwer, Taryn Young, Charlotte M Bavuma, Joerg J Meerpohl   +4 more
doaj   +1 more source

Surgical-DINO: Adapter Learning of Foundation Models for Depth Estimation in Endoscopic Surgery [PDF]

arXiv
Purpose: Depth estimation in robotic surgery is vital in 3D reconstruction, surgical navigation and augmented reality visualization. Although the foundation model exhibits outstanding performance in many vision tasks, including depth estimation (e.g., DINOv2), recent works observed its limitations in medical and surgical domain-specific applications ...
arxiv  

Combined spatially resolved metabolomics and spatial transcriptomics reveal the mechanism of RACK1‐mediated fatty acid synthesis

Molecular Oncology, EarlyView.
The authors analyzed the spatial distributions of gene and metabolite profiles in cervical cancer through spatial transcriptomic and spatially resolved metabolomic techniques. Pivotal genes and metabolites within these cases were then identified and validated.
Lixiu Xu, Jinqiu Li, Junqi Ma, Ayshamgul Hasim   +3 more
wiley   +1 more source