Results 161 to 170 of about 1,630,396 (293)

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

Molecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski, Molly R. Danks, John P. Thomson, Morwenna Muir, Martin Lee, John C. Dawson, Ana T. Amaral, Juan Diaz‐Martin, David S. Moura, Javier Martin‐Broto, Ali Alsaadi, Donald M. Salter, Ailsa J. Oswald, Graeme Grimes, Larry Hayward, Ted R. Hupp, Karen Sisley, Paul H. Huang, Neil O. Carragher, Valerie G. Brunton   +19 more
wiley   +1 more source

A collapse risk assessment method for subway foundation pit based on cloud model and improved Dempster–Shafer evidence theory [PDF]

Bo Wu, Jiajia Zeng, Ruonan Zhu, Fan Yang, Cong Liu, Yundong Xie   +5 more
openalex   +1 more source

The subcellular distribution of phosphorylated Y‐box‐binding protein‐1 at S102 in colorectal cancer patients, stratified by KRAS mutational status and clinicopathological features

Molecular Oncology, EarlyView.
This study identifies nuclear YB‐1 S102 phosphorylation as a marker associated with KRAS and FBXW7 mutations in colorectal cancer. Mutated KRAS correlates specifically with nuclear, not cytoplasmic, S102 YB‐1. These findings provide the first ex vivo evidence of this link in CRC and suggest future studies should assess the prognostic and therapeutic ...
Konstanze Lettau, Stephan Forchhammer, Birgit Fehrenbacher, Lejla Mahmutovic, Marcus Scharpf, Gunnar Blumenstock, Martin Schaller, Irina Bonzheim, Shayan Khozooei, Mahmoud Toulany   +9 more
wiley   +1 more source

Exploring evidence gaps in clinical trials in thermal burns care: an umbrella review. [PDF]

BMJ Open
Richards HS, Qureshi R, Kinsella S, Dawson S, Staruch R, Lee A, Meirte J, Evans J, Stiles K, Martin N, Dheansa B, Blazeby J, Savović J, Young A.   +13 more
europepmc   +1 more source

CopilotCAD: Empowering Radiologists with Report Completion Models and Quantitative Evidence from Medical Image Foundation Models [PDF]

Sheng Wang, Tianming Du, Katherine Fischer, Gregory E. Tasian, Justin Ziemba, Joanie M. Garratt, Hersh Sagreiya, Yong Fan   +7 more
openalex   +1 more source

The Empirical Zoo Director—Building a Foundation of Evidence-Based Welfare and Wellness: Keynote [PDF]

, 2013
Terry L. Maple
openalex   +1 more source

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

Implementing evidence into practice for the management of frozen shoulder: engaging with key stakeholders and evaluating barriers and facilitators using the Consolidated Framework for Implementation Research. [PDF]

Health Res Policy Syst
Clark NL, Johnson M, Kottam L, Brealey S, Adamson J, Rangan A, UK FROST Stakeholder Group.   +6 more
europepmc   +1 more source

Evidence‐based knowledge on the aesthetics and maintenance of peri‐implant soft tissues: Osteology Foundation Consensus Report Part 1—Effects of soft tissue augmentation procedures on the maintenance of peri‐implant soft tissue health [PDF]

, 2018
William V. Giannobile, Ronald E. Jung, Frank Schwarz   +2 more
openalex   +1 more source

Severity and Trustworthy Evidence: Foundational Problems versus Misuses of Frequentist Testing

, 2022
Aris Spanos
openalex   +1 more source