Results 181 to 190 of about 1,900,275 (265)

Glucagon-Like Peptide-1 Receptor Agonists as a Potential Mitochondrial Modulation Therapy for Hidradenitis Suppurativa. [PDF]

Acta Derm Venereol
Hosseini A, Von Gunten S, Hunger RE, Zouboulis CC, Seyed Jafari SM.   +4 more
europepmc   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Holistic management of juvenile idiopathic arthritis across all ages: British Society for Rheumatology Guideline scope. [PDF]

Rheumatol Adv Pract
Compeyrot-Lacassagne S, Beesley RP, Bray L, Bridges A, Chaplin H, Ciurtin C, Cleary G, Cooray S, Aragon Cuevas O, Cuthbert V, Deepak S, Earle E, Ferreira A, Kearsley-Fleet L, Gupta J, Houston R, Hum RM, Humphreys JH, Jayasekera HS, Jones S, MacFadyen C, Nisbet J, Arunath V, Prior Y, Rogers V, Shoop-Worrall SJW, Solebo AL, Waller R, Williamson LD, Wilson D, Wright C, Sen ES, British Society for Rheumatology Guideline Steering Group .   +32 more
europepmc   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

<i>Correction</i>: Introducing artificial intelligence in acute psychiatric inpatient care: qualitative study of its use to conduct nursing observations. [PDF]

BMJ Ment Health
europepmc   +1 more source

Integrated multi-omics strategies for identifying novel therapies in psoriasis. [PDF]

Bioinformatics
Si S, Wang X, Wang X, Zhan S.
europepmc   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

A cross-sectional retrospective and prospective service evaluation of head and neck cancer patients' swallowing and quality of life concerns: are we doing enough? [PDF]

Support Care Cancer
Rothrie S, Brady G, Roe J.
europepmc   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Empowering the future of evidence‐based healthcare: The Cochrane Early Career Professionals Network

Cochrane Evidence Synthesis and Methods
Ana Beatriz Pizarro, Santiago Castiello‐de Obeso, Ahmad Sofi‐Mahmudi, Robin Vernooij, Elpida Vounzoulaki, Chris Champion   +5 more
doaj   +1 more source