Results 191 to 200 of about 2,029,114 (264)

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Evidence for Dose Optimization of Immune Checkpoint Inhibitors. [PDF]

J Immunother Precis Oncol
Limaye S, Noronha V, Prabhash K.
europepmc   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Empowering the future of evidence‐based healthcare: The Cochrane Early Career Professionals Network

Cochrane Evidence Synthesis and Methods
Ana Beatriz Pizarro, Santiago Castiello‐de Obeso, Ahmad Sofi‐Mahmudi, Robin Vernooij, Elpida Vounzoulaki, Chris Champion   +5 more
doaj   +1 more source

Cross-linguistic Evidence for Cognitive Foundations of Polysemy.

, 2014
Zhu, Huichun, Malt, Barbara C.
openaire   +1 more source

Research priorities and knowledge gaps in understanding hepatobiliary disease in cystic fibrosis. [PDF]

Hepatol Commun
Debray D, Hunt WR, Bodewes F, Hempstead SE, Peckham D, Petit RS, Philbrick A, Narkewicz M, Sellers ZM, Assis DN, Sathe M, CF Foundation Hepatobiliary Guidelines Committee.   +11 more
europepmc   +1 more source

Evaluating Sequence Foundation Models for Insect Olfactory Gene Discovery: Failure Modes, Evidence Standards, and a Benchmark Agenda. [PDF]

Insects
Li H, Zhou D, Pu W, Wu G, Xiao C, Gao X, Yu J.   +6 more
europepmc   +1 more source

Characterising Hepatitis D Virus in the UK From 2011 to 2021. [PDF]

J Viral Hepat
Simmons R, Ijaz S, Jackson R, Jack K, Mulongeni R, Raghu R, Riddell A, Elsharkawy A, Uriel A, Koffas A, Chaika A, Lawson A, Cole A, McEwan A, Brown A, Stone B, Levick C, Byrne D, Forton D, MacDonald D, Forde D, Nastouli E, Barnes E, Sumner E, Page E, Carey I, Vilar FJ, Maggs J, Collier J, Shepherd J, Agarwal K, Bicknell K, Ala K, Dear K, Ratcliffe L, Bruce M, Zhang H, Rivett L, Maes M, Ankcorn M, Aldersley M, Prince M, Lemoine M, Foxton M, Wright M, Cramp M, Wiselka M, Easom N, Richardson P, Gunson R, Herbert R, Blackwell R, Jelley R, Aspinall R, Simpson R, Clewes R, Ahmad S, Mcpherson S, Ryder S, Verma S, Lampejo T, Sathyanarayana V, Gelson W, Leeman D, Desai M, Mandal S, Kennedy PT, Irving WL.   +67 more
europepmc   +1 more source

Cognition endpoints for Parkinson's disease: A roadmap for developing patient-focused assessment tools to accelerate drug development. [PDF]

J Parkinsons Dis
Edgar CJ, Poston KL, Coon CD, Bocell FD, Dam T, Xiao Y, Kopil CM, Simuni T, Weintraub D, Thomas M.   +9 more
europepmc   +1 more source