Results 201 to 210 of about 4,690,912 (308)

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Managing Blood Pressure in Dialysis Patients: A Summary of UK Clinical Practice Guideline. [PDF]

Kidney Int Rep
Dasgupta I, Adam M, Durman K, Fan SLS, Forbes A, Jenkinson E, Mallindine C, McCaffery K, Sinha MD, Stewart D, Swift PA, Doulton TWR.   +11 more
europepmc   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Diagnosis and management of paediatric magnet ingestion: a systematic review of clinical practice guidelines. [PDF]

Emerg Med J
Nezhentsev A, Neville JJ, Hall NJ.
europepmc   +1 more source

Molecular cancer prevention: Intercepting disease

Molecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
wiley   +1 more source

Serum ferritin level and morbidity risk in transfusion-independent patients with β-thalassemia intermedia: the ORIENT study

Haematologica, 2014
Khaled M. Musallam, Maria Domenica Cappellini, Shahina Daar, Mehran Karimi, Amal El-Beshlawy, Giovanna Graziadei, Matthew Magestro, Jerome Wulff, Guilhem Pietri, Ali T. Taher   +9 more
doaj   +1 more source

Population discontinuity in the Paris Basin linked to evidence of the Neolithic decline. [PDF]

Nat Ecol Evol
Seersholm FV, Ramsøe A, Cao J, Chambon P, Sjögren KG, McColl H, Demeter F, Gaunitz C, Vinner L, Stenderup J, Scorrano G, Fyfe R, Price TD, Mortensen MF, Krüger S, Dehn T, Hansen SI, Vesterdorf K, Korneliussen TS, Allentoft ME, Kristiansen K, Salanova L, Willerslev E, Sikora M.   +23 more
europepmc   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Comparing the sleep benefits of Nature-Based Interventions: Evidence from a Bayesian Network meta-analysis. [PDF]

iScience
Ma C, Shah AM, Chen W, Li Z, Peng Y, Wu R, Du X, Li H, Lv B, Liu S, Chen Q.   +10 more
europepmc   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source