Results 181 to 190 of about 1,630,396 (293)
Evidence map of nutrient interventions for major depression: a systematic review protocol. [PDF]
Syst RevZhang D, Li C, Tian X, Miao G, Shi W, Lu H, Qu Y, Cai M, Tang Y, Shen H, Gao B. +10 moreeuropepmc +1 more sourceTumor clusters with divergent inflammation and human retroelement expression determine the clinical outcome of patients with serous ovarian cancer
Molecular Oncology, EarlyView.Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...Laura Glossner, Markus Eckstein, Christoph Mark, Matthias W. Beckmann, Arndt Hartmann, Pamela L. Strissel, Reiner Strick +6 morewiley +1 more sourceEffect of <i>CYP1A2</i>, <i>CYP2D6</i>, and <i>CYP3A4</i> Variation on Antipsychotic Treatment Outcomes. [PDF]
Pharmaceuticals (Basel)Varney L, Murtough S, Cotic M, Abidoph R, Chan L, Saadullah Khani N, Richards-Belle A, Richards-Brown M, Mills D, Panconesi D, Dawda Y, Sharma P, Shah C, Secchi A, Nilforooshan R, Mudholkar S, Murdoch R, Molai J, Griffiths R, Senthilkumar S, Blake H, Lankshear S, McRoberts J, Pastor B, Thomas C, Richards S, Welfare-Wilson A, Cheung SB, Cox R, Jibero AC, Anad R, Laczik R, Ghali S, Berry AJ, Curwen J, Odutoye K, Kottalgi G, Williams S, Wong S, Anandan N, Pius G, Ajiteru T, Clark V, van Driel P, Bashir A, Court S, Pawsey M, Skowronska A, Woodley J, Bramon E. +49 moreeuropepmc +1 more sourceEvaluation and modification of tumor cell isolation techniques from malignant effusions for rapid drug sensitivity testing
Molecular Oncology, EarlyView.Non‐small cell lung cancer targeted treatment is limited to a few known genetic alterations, with few alternatives in advanced treatment lines. To direct treatment decisions by drug sensitivity testing (DST), this study compared several methods for tumor cell isolation from malignant effusions, pointing to repeated CD45+ cell depletion for effective ...Navit Mooshayef, Hana Barhom, Sumit Chatterji, Netta Hecht, Oran Warhaftig, Iris Kamer, Oranit Zadok, Jair Bar, Limor Broday, Amir Onn, Michael Peled +10 morewiley +1 more sourceConserved missense variant pathogenicity and correlated phenotypes across paralogous genes. [PDF]
Genome BiolBrünger T, Ivaniuk A, Pérez-Palma E, Montanucci L, Cohen S, Smith L, Parthasarathy S, Helbig I, Nothnagel M, May P, Lal D. +10 moreeuropepmc +1 more sourceCytomegalovirus infection is common in prostate cancer and antiviral therapies inhibit progression in disease models
Molecular Oncology, EarlyView.Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...Johanna Classon, Moa Stenudd, Margherita Zamboni, Kanar Alkass, Carl‐Johan Eriksson, Lars Pedersen, Alrik Schörling, Anna Thoss, Anders Bergh, Pernilla Wikström, Hans‐Olov Adami, Henrik Toft Sørensen, Henrik Druid, Jonas Frisén +13 morewiley +1 more sourceComment on "Reduced temporal muscle thickness predicts shorter survival in patients undergoing chronic subdural haematoma drainage" by Korhonen et al.-The authors' reply. [PDF]
J Cachexia Sarcopenia MuscleKorhonen TK, Arponen O, Steinruecke M, Pecorella I, Mee H, Yordanov S, Viaroli E, Guilfoyle MR, Kolias A, Timofeev I, Hutchinson P, Helmy A. +11 moreeuropepmc +1 more sourceIntegrative miRNOMe profiling reveals the miR‐195‐5p–CHEK1 axis and its impact on luminal breast cancer outcomes
Molecular Oncology, EarlyView.In luminal (ER+) breast carcinoma (BC), miRNA profiling identified miR‐195‐5p as a key regulator of proliferation that targets CHEK1, CDC25A, and CCNE1. High CHEK1 expression correlates with worse relapse‐free survival after chemotherapy, especially in patients with luminal A subtype.Veronika Boušková, Marie Ehrlichová, Alžběta Spálenková, Ivona Krus, Simona Šůsová, Viktor Hlaváč, Vlasta Němcová, Renata Koževnikovová, Markéta Trnková, David Vrána, Jiří Gatěk, Kateřina Kopečková, Marcela Mrhalová, Soňa Měšťáková, Pavel Souček +14 morewiley +1 more sourceAnalysis of more than 400,000 women provides case-control evidence for BRCA1 and BRCA2 variant classification. [PDF]
Nat CommunZanti M, O'Mahony DG, Parsons MT, Dorling L, Dennis J, Boddicker NJ, Chen W, Hu C, Naven M, Yiangou K, Ahearn TU, Ambrosone CB, Andrulis IL, Antoniou AC, Auer PL, Baynes C, Bodelon C, Bogdanova NV, Bojesen SE, Bolla MK, Brantley KD, Camp NJ, Campbell A, Castelao JE, Cessna MH, Chang-Claude J, Chen F, Chenevix-Trench G, NBCS Collaborators, Conroy DM, Czene K, De Nicolo A, Domchek SM, Dörk T, Dunning AM, Eliassen AH, Evans DG, Fasching PA, Figueroa JD, Flyger H, Gago-Dominguez M, García-Closas M, Glendon G, González-Neira A, Grassmann F, Hadjisavvas A, Haiman CA, Hamann U, Hart SN, Hartman MBA, Ho WK, Hodge JM, Hoppe R, Howell SJ, kConFab Investigators, Jakubowska A, Khusnutdinova EK, Ko YD, Kraft P, Kristensen VN, Lacey JV, Li J, Lim GH, Lindström S, Lophatananon A, Luccarini C, Mannermaa A, Martinez ME, Mavroudis D, Milne RL, Muir K, Nathanson KL, Nuñez-Torres R, Obi N, Olson JE, Palmer JR, Panayiotidis MI, Patel AV, Pharoah PDP, Polley EC, Rashid MU, Ruddy KJ, Saloustros E, Sawyer EJ, Schmidt MK, Southey MC, Tan VK, Teo SH, Teras LR, Torres D, Trentham-Dietz A, Truong T, Vachon CM, Wang Q, Weitzel JN, Yadav S, Yao S, Zirpoli GR, Cline MS, Devilee P, Tavtigian SV, Goldgar DE, Couch FJ, Easton DF, Spurdle AB, Michailidou K. +105 moreeuropepmc +1 more source
