Results 171 to 180 of about 10,003,521 (346)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

General-Purpose Vision Models to Dermatology-Specific Foundation Models: Comparative Evaluation for Facial Skin Disease Classification

Uchenna Esther Okpete, Md Ariful Islam Mozumder, Osita Sunday Nnyigide, Haewon Byeon, Hee-Cheol Kim   +4 more
openalex   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Tracing the rise of biomedical foundation models. [PDF]

Nat Biotechnol
Chang Y, Cheng H, Modi M, Wang G, Xu D, Ma Q.   +5 more
europepmc   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Foundation models for cardiovascular diseases and medicine. [PDF]

Eur Heart J Digit Health
Ye J, Bronstein S, Hashish MA.
europepmc   +1 more source

Distributed Tensor and Pipeline Parallelism for Trillion-Parameter Foundation Models: Communication Topologies, 3D/4D Parallel Scaling, and Fault-Tolerant Checkpointing

Anuj Kumawat, Hemant, Vishal Shrivastava, Vibhakar Pathak   +3 more
openalex   +1 more source

Erickson Educational Foundation Newsletter, Vol. 03, No. 01 (Spring 1970)

, 1970
A newsletter by the Erickson Educational Foundation containing information and resources for and about "transexual" people and "transexualism"
Erickson Educational Foundation
core  

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source