Results 191 to 200 of about 10,003,521 (346)
Translophagy—A potential link between autophagy impairment and translational errors
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Decoding the host-microbiome dialogue with biological foundation models. [PDF]
eBioMedicine.
europepmc +1 more source
Premakant, Rajeev Kumar, Madhusmita Singh, Dr. Vishal Shrivastava, Dr. Akhil Pandey, Dr.Rakesh Ranjan
openalex +1 more source
Laying an equitable data foundation for foundation models
openaire +2 more sources
Structural and biochemical analysis of a B12 superbinder
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Representation Transfer of Foundation Models for Ultra-Widefield Retinal Imaging. [PDF]
Gong MA +9 more
europepmc +1 more source
Ensuring the Validity of the Micro Foundation in DSGE Models
The presence of i) stochastic trends, ii) deterministic trends, and/or iii) stochastic volatil- ity in DSGE models may imply that the agents' objective functions attain infinite values. We say that such models do not have a valid micro foundation.
Martin Møller Andreasen
core
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source

