Results 291 to 300 of about 10,003,521 (346)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Microscopy Cell Segmentation: Review and Benchmarking of Task-Specific and Foundation Models. [PDF]

J Imaging
Martí-Pérez D, Naranjo V, Colomer A.
europepmc   +1 more source

Balancing Foundation Models and Trait-Specific Learning for Forehead-Crease Recognition

Geetanjali Sharma, Aryan Jain, Dev Nagaich, Aditya Nigam, Raghavendra Ramachandra   +4 more
openalex   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Established machine learning matches tabular foundation models in clinical predictions. [PDF]

BMC Med Inform Decis Mak
Shaktah LA, Gustav M, Lenz T, Liang J, Hilgers L, Carrero ZI, Kather JN.   +6 more
europepmc   +1 more source

Bridging the deployment gap in automated moth monitoring through biodiversity foundation models

Yu-Cheng Wei, Li-Cheng Shih, Yanting Lai, Chung-Liang Lin, 陸聲山, Ming‐Tang Shiao   +5 more
openalex   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Foundation Models for Remote Sensing Semantic Segmentation: A Review of Architectures, Adaptations, and Prospects. [PDF]

Sensors (Basel)
Deng M, Chen Y, Ding G, Li S, Xie X.
europepmc   +1 more source

Data-Centric Recursive Improvement for Foundation Models: A Survey

Yanyan Zou, Chao Chen, Tung Sum Thomas Kwok, Jiayu Yang, Yunyun Hou, Jingmin Zhu, Zehang Luo, Shengjie Li, Yinhong Liu, Yingjia Wan, Chengzu Li, Tao Yu, Zhijiang Guo, Jiachen Liu, Sirui Wang, Nan Duan   +15 more
openalex   +1 more source

Foundation Models for Microbiome Research: From Sequence Semantics to Community Dynamics and Multimodal World Models. [PDF]

Adv Genet (Hoboken)
Zhang H, Kang Z, Ning K.
europepmc   +1 more source