Results 71 to 80 of about 255,075 (301)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Stochastic Stackelberg games

open access: yes, 2020
In this paper, we consider a discrete-time stochastic Stackelberg game where there is a defender (also called leader) who has to defend a target and an attacker (also called follower).
Vasal, Deepanshu
core  

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

Heat engine in the three-dimensional spacetime

open access: yes, 2017
We define a kind of heat engine via three-dimensional charged BTZ black holes. This case is quite subtle and needs to be more careful. The heat flow along the isochores does not equal to zero since the specific heat $C_V\neq0$ and this point completely ...
Li, Gu-Qiang, Liang, Feng, Mo, Jie-Xiong
core   +1 more source

African-European contacts in the Kongo Kingdom (sixteenth-eighteenth centuries): new archaeological insights from Ngongo Mbata (Lower Congo, DRC) [PDF]

open access: yes, 2015
Ngongo Mbata, the main and most affluent center of the Kongo kingdom’s Mbata province in the 17th century, is well known from the historical sources, but virtually unexplored in archaeological publications.
Bostoen, Koen   +7 more
core   +3 more sources

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

Study on the Influence and Deformation Control of Rich Water Foundation Excavation on Adjacent Buildings

open access: yesBuildings
Taking the foundation pit of the Suzhou Chunshenhu Road Expressway Reconstruction Project as an example, the excavation process of the foundation pit was numerically simulated using a three-dimensional finite element method.
Zhouya Wang   +4 more
doaj   +1 more source

The Research Review on Monitoring of Foundation Pit [PDF]

open access: yesProceedings of the 4th International Conference on Information Technology and Management Innovation, 2015
KEYWORD: Monitoring of Foundation pit, Construction safety, Technology development, Problem ABSTRACT: With the development of the city, the underground space are used in different ways at every city over the world, such us Multilayer basement of high-rise building, subway, underground market, as well as a variety of underground civil and industrial ...
X.Q Wang   +4 more
openaire   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

open access: yesFEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman   +4 more
wiley   +1 more source

Necessity of Inverted Supports in the Inclined Strut Section of the Foundation Pit with Strip Bottom Plate and Diaphragm Wall

open access: yesChengshi guidao jiaotong yanjiu
[Objective] In order to save project investment, strip bottom plates that are not fully closed are used for the foundation pit bottom sealing in some foundation pit inclined strut sections. After the removal of the lowest supports in such foundation pits,
YANG Kaiwu   +4 more
doaj   +1 more source

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