Results 61 to 70 of about 1,969,766 (248)

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Study on the Influence and Deformation Control of Rich Water Foundation Excavation on Adjacent Buildings

Buildings
Taking the foundation pit of the Suzhou Chunshenhu Road Expressway Reconstruction Project as an example, the excavation process of the foundation pit was numerically simulated using a three-dimensional finite element method.
Zhouya Wang, Xiaole Shen, Xiaoxu Tian, Zhanping Song, Pengyuan Zhou   +4 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Research on the Stress and Deformation Characteristics of Circular Foundation Pit during Excavation in Sand Soil

Advances in Materials Science and Engineering, 2023
The stress and deformation response characteristics of the support structure in the process of excavation and support of circular sand foundation pit are complex.
Xuhe Gao, Weiping Tian, Jiachun Li, Hongliang Qi, Shiyang Li, Zhipei Zhang   +5 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Necessity of Inverted Supports in the Inclined Strut Section of the Foundation Pit with Strip Bottom Plate and Diaphragm Wall

Chengshi guidao jiaotong yanjiu
[Objective] In order to save project investment, strip bottom plates that are not fully closed are used for the foundation pit bottom sealing in some foundation pit inclined strut sections. After the removal of the lowest supports in such foundation pits,
YANG Kaiwu, LUO Zhenggao, JIANG Mingwei, ZHU Jianxun, YANG Chunyang   +4 more
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Solution of Water Inflow and Water Level Outside the Curtain of Strip Foundation Pit with Suspended Waterproof Curtain in the Phreatic Aquifer

Applied Sciences
The seepage field of a suspended waterproof curtain strip foundation pit in a deep phreatic aquifer is theoretically analyzed, and a calculation method for the foundation pit water inflow and water level outside the curtain is derived.
Da Li, Ningyi Liu, Jiahe Han, Junhong Shen   +3 more
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Safety Resilience Evaluation of Deep Foundation Pit Construction Based on Extension Cloud Model

Buildings
Deep foundation pit construction faces significant safety challenges—including frequent accidents and severe disaster consequences—due to inherent complexity and uncertainty.
Xiaojian Guo, Jiayi Mao, Luyun Wang, Jianglin Gu   +3 more
doaj   +1 more source