Results 101 to 110 of about 108,171 (302)
Founder Effect: Assessment of Variation in Genetic Contributions among Founders
, 2016 We present a Monte Carlo method for determining the distribution of founders’ genetic contributions to descendant cohorts. The simulation of genes through known pedigrees generates the probability distributions of contributed genes in recent cohorts of ...
Rogers, A R +3 more
core
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
The Role of Founder-CEOs and Founder-Families in IPOs
, 2019 This paper shows that in large U.S. companies, founder-CEO and founder-family controlled firms experience about 10 percent more underpricing relative to non-founder firms during the IPO process.
Duan, Xiaoman, Niu, Xu
core
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Founder Succession and Accounting Properties [PDF]
Using a sample of 231 entrepreneurial firm successions in Hong Kong, Singapore, and Taiwan, we find that firms' unsigned discretionary accruals decrease while timely loss recognition increases subsequent to successions, suggesting a shift in accounting ...
Fan, Joseph P.H. +2 more
core
Epistasis between Founder gene deletion and evolved mutations.
, 2019 (A) Relationship between the fitness effects of evolved mutations in the Founder deletion background compared to their effect in the wild type background. Boxed region shows area expanded in (B).
Sergey Kryazhimskiy (17955) +3 more
core +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
The importance of anthropological genetics research in Honduras, Central America
Revista Argentina de Antropología BiológicaWith its unique geographic location at the northern end of the Central American isthmus, Honduras straddles the boundaries of two distinct cultural regions—the Mesoamerican and the Istmo-Colombian.
Norberto F. Baldi, Edwin F. Herrera Paz
doaj +1 more source