Results 151 to 160 of about 106,656 (261)

Mucopolysaccharidosis type I: founder effect of the p.P533R mutation in North Africa. [PDF]

BMC Genomics
Chkioua L, El Fissi H, Amri Y, Sahli C, Bouzid F, Boudabous H, Tbib N, Ferchichi S, Massoud T, Alif N, Laradi S, Ben Abdennebi H.   +11 more
europepmc   +1 more source

Prevalent Pathogenic Variants of ATP7B in Chinese Patients with Wilson's Disease: Geographical Distribution and Founder Effect. [PDF]

Genes (Basel), 2021
Yang GM, Wang RM, Xia N, Zheng ZW, Dong Y, Wu ZY.   +5 more
europepmc   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Inherited CARD9 Deficiency Due to a Founder Effect in East Asia. [PDF]

J Clin Immunol
Tomomasa D, Lee BH, Hirata Y, Inoue Y, Majima H, Imanaka Y, Asano T, Katakami T, Lee J, Hijikata A, Worakitchanon W, Yang X, Wang X, Watanabe A, Kamei K, Kageyama Y, Seo GH, Fujimoto A, Casanova JL, Puel A, Morio T, Okada S, Kanegane H.   +22 more
europepmc   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Extreme founder effect associated with hyperglycemia and hyperlipidemia on the island of NIAS/Indonesia. [PDF]

Atheroscler Plus
Kennerknecht I, Hämmerle JM, Fobker M, Nofer JR.   +3 more
europepmc   +1 more source

Evidence for human-caused founder effect in populations of Solanum jamesii found at archaeological sites: I. Breeding experiments and the geography of sexual reproduction. [PDF]

Am J Bot, 2021
Pavlik BM, Baker M, Bamberg J, Del Rio A, Kinder D, Louderback LA.   +5 more
europepmc   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Successes of an innovative population-based carrier screening program for 4 prevalent recessive hereditary diseases in a population with a founder effect in Quebec, Canada. [PDF]

Genet Med Open
Fortin CA, Côté-Richer M, Truchon K, Leblanc J, Pratte A, Tardif J, Thomas MJ, Villeneuve J, Mathieu J, Grimard D, Desmeules M, Moreau C, Girard S, Cruz-Marino T, Bouchard L.   +14 more
europepmc   +1 more source

The Viral Founder Effect and Economic-Driven Human Mobility Shaped the Distinct Epidemic Pattern of HIV-1 CRF01_AE in Northeast China. [PDF]

Front Med (Lausanne), 2021
An M, Zhao B, Wang L, Chu Z, Xu J, Ding H, Han X, Shang H.   +7 more
europepmc   +1 more source