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Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
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Founder effect in crop-plant evolution
Economic Botany, 1985Seed-crop plants apparently originated from a limited number of mutants in which seed dispersal was changed from that found in nondomesticated populations. Seed nonshattering in cultivated plants may be controlled by a single gene or a small number of genes.
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Parent firm effects on founder turnover: parent success, founder legitimacy, and founder tenure
Strategic Entrepreneurship Journal, 2010Abstract Empirical studies examining new ventures have demonstrated a significant degree of founder turnover after start‐up as founders are replaced by ‘professional’ managers. We examine how founders' past experience in their prior employer (their parent firm) affects their tenure in the new venture.
Warren Boeker, Brandon Fleming
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Fragile X founder effects in Argentina
American Journal of Medical Genetics, 1998To investigate the origin of fragile X mutations in the Argentine population, we studied the alleles and haplotypes at DXS548 and FRAXAC1 loci of 42 unrelated fragile X chromosomes and 168 normal ones. Four haplotypes presented in linkage disequilibrium and accounted for 76.2% of fragile X chromosomes, representing the high frequency of haplotype ...
G, Bonaventure +3 more
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Possible founder effects for FRAXE alleles
American Journal of Medical Genetics, 1999To determine if FRAXE alleles may have haplotype associations with nearby microsatellites, we analyzed 149 unrelated control Caucasian X chromosomes for FRAXE GCC alleles along with five nearby microsatellites. The microsatellites included three that are new; GT25, CA4, and CA5 located approximately 24, approximately 48, and approximately 50 kb ...
P, Limprasert +3 more
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Investigation on the founder effect
Genetica, 1974The fitness of threeDrosophila melanogaster populations (A,B,C) and the crosses between them (A×B; A×C; B×C) has been studied in conditions of overlapping generations. Each line was subdivided into 4 sub-populations (1,2,3,4) differing in the phenotype of the founder flies (vestigial or wild type) and of which sub-populations 2 and 3 had the same gene ...
D. L. Palenzona, M. Mochi, E. Boschieri
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Genetic Revolutions, Founder Effects, and Speciation
Annual Review of Ecology and Systematics, 1984Are new species formed in rare catastrophes, distinct from the normal processes of phyletic evolution? Or does reproductive isolation evolve gradually, as a by-product of the divergence of gene pools? Mayr (120-124) has argued the former, holding that speciation usually results from genetic revolutions triggered by founder effects: An isolated ...
N H Barton, B Charlesworth
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Dramatic founder effects in Amerindian mitochondrial DNAs
American Journal of Physical Anthropology, 1985AbstractSouthwestern American Indian (Amerindian) mitochondrial DNAs (mtDNAs) were analyzed with restriction endonucleases and found to contain Asian restriction fragment length polymorphisms (RFLPs) but at frequencies very different from those found in Asia. One rare Asian HincII RFLP was found in 40% of the Amerindians. Several mtDNAs were discovered
D C, Wallace, K, Garrison, W C, Knowler
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Founder Effect Speciation: A Theoretical Reassessment
The American Naturalist, 1996We propose a series of simple models of founder effect speciation. In these models, the resulting reproductive isolation (as measured by the proportion of inviable hybrids or the strength of the barrier to gene exchange between populations) can be very high and can evolve with a high probability on the time scale of dozens or hundreds of generations ...
Sergey Gavrilets, Alan Hastings
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