Results 41 to 50 of about 703,061 (267)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Two positive solutions for nonlinear fourth-order elastic beam equations
Electronic Journal of Qualitative Theory of Differential Equations, 2019 The aim of this paper is to study the existence of at least two non-trivial solutions to a boundary value problem for fourth-order elastic beam equations given by \begin{align*} u^{(4)}+Au''+Bu = \lambda f(x,u) \quad \text{in } [0,1],\\ u(0) =u(1)
Giuseppina D'Aguì +2 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Hyperbolic Relaxation of a Fourth Order Evolution Equation
Abstract and Applied Analysis, 2013 We propose a hyperbolic relaxation of a fourth order evolution equation, with an inertial term , where . We prove the existence of several absorbing sets having different regularities and the existence of a global attractor that is bounded in .
Renato Colucci, Gerardo R. Chacón
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Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Institutions as Objects in Fourth Order Design
She Ji: The Journal of Design, Economics and InnovationFourth order design, which involves systems and environments, is a frequently misunderstood area of design. The concept of institution offers a way to clarify and enrich fourth order design in both theory and practice.
Kipum Lee
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Riccati Technique and Asymptotic Behavior of Fourth-Order Advanced Differential Equations
Mathematics, 2020 In this paper, we deal with the oscillation of fourth-order nonlinear advanced differential equations of the form r t y ‴ t α ′ + p t f y ‴ t + q t g y σ t = 0 .
Omar Bazighifan, Ioannis Dassios
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Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Jumping nonlinearities for fourth order B.V.P. [PDF]
Annales de la Faculté des sciences de Toulouse : Mathématiques, 1993 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
García-Huidobro, Marta +1 more
openaire +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source