Results 51 to 60 of about 10,905,906 (292)

Nontrivial Solutions of a Class of Fourth-Order Elliptic Problems with Potentials

Fractal and Fractional, 2022
This paper deals with a fourth-order elliptic equation with Dirichlet boundary conditions. Using a variant form of the mountain pass theorem, we prove the existence of nontrivial solutions to this problem.
Jiabin Zuo, Zakaria El Allali, Said Taarabti   +2 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Global existence and blow-up of solution to a class of fourth-order equation with singular potential and logarithmic nonlinearity

Electronic Journal of Qualitative Theory of Differential Equations, 2023
In this paper, we consider the well-posedness and asymptotic behavior of Dirichlet initial boundary value problem for a fourth-order equation with strong damping and logarithmic nonlinearity. We establish the local solvability by the technique of cut-off
Xiulan Wu, Yaxin Zhao, Xiaoxin Yang
doaj   +1 more source

Exploring the Fourth Order

Conference Proceedings of the Academy for Design Innovation Management, 2019
Companies are organised to fulfil two distinctive functions: efficient and resilient exploitation of current business and parallel exploration of new possibilities. For the latter, companies require strong organisational infrastructure such as team compositions and functional structures to ensure exploration remains effective.
Barend KLITSIE, Rebecca PRICE, Christine DE LILLE   +2 more
openaire   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Fourth Order MCA and Chaos-Based Image Encryption Scheme

IEEE Access, 2019
This paper presents a fast and efficient cryptosystem for enciphering digital images. It employs two of the most prominent dynamical systems-chaotic maps and cellular automata.
Aslam Li, Akram Belazi, Sofiane Kharbech, Muhammad Talha, Wei Xiang   +4 more
doaj   +1 more source

Effective-fourth-order resonator based MASH bandpass sigma-delta modulators

, 1997
Two novel effective-fourth-order (eighth-order) resonator based MASH (MultistAge noise SHaping) bandpass Σ-Δ modulators are introduced at the behavioural level and subsequently examined by simulations utilising the ALTA SPW environment.
Morling, R.C.S., Kale, I., Al-Janabi, M.
core   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source