Results 51 to 60 of about 853,118 (283)

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Two positive solutions for nonlinear fourth-order elastic beam equations

Electronic Journal of Qualitative Theory of Differential Equations, 2019
The aim of this paper is to study the existence of at least two non-trivial solutions to a boundary value problem for fourth-order elastic beam equations given by \begin{align*} u^{(4)}+Au''+Bu = \lambda f(x,u) \quad \text{in } [0,1],\\ u(0) =u(1)
Giuseppina D'Aguì, Beatrice Di Bella, Patrick Winkert   +2 more
doaj   +1 more source

Lessons Learned From a Delayed‐Start Trial of Modafinil for Freezing of Gait in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Freezing of gait (FOG) in people with Parkinson's disease (PwPD) is debilitating and has limited treatments. Modafinil modulates beta/gamma band activity in the pedunculopontine nucleus (PPN), like PPN deep brain stimulation. We therefore tested the hypothesis that Modafinil would improve FOG in PwPD.
Tuhin Virmani, Lakshmi Pillai, Reid D. Landes, Aliyah Glover, Shannon Doerhoff, Jennifer Kleiner, Mitesh Lotia, Rohit Dhall, Edgar Garcia‐Rill   +8 more
wiley   +1 more source

Hyperbolic Relaxation of a Fourth Order Evolution Equation

Abstract and Applied Analysis, 2013
We propose a hyperbolic relaxation of a fourth order evolution equation, with an inertial term , where . We prove the existence of several absorbing sets having different regularities and the existence of a global attractor that is bounded in .
Renato Colucci, Gerardo R. Chacón
doaj   +1 more source

Characterization of Clinical Phenotype to Glial Fibrillary Acidic Protein Concentrations in Alexander Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine the concentration of glial fibrillary acidic protein (GFAP) in cerebrospinal fluid (CSF) and plasma in Alexander disease (AxD) and whether GFAP levels are predictive of disease phenotypes. Methods CSF and plasma were collected (longitudinally when available) from AxD participants and non‐AxD controls.
Amy T. Waldman, Asako Takanohashi, Joshua Y. Joung, Geraldine W. Liu, Kaley Arnold, Amy Pizzino, Walter Faig, Sarah Woidill, Sona Narula, Adeline L. Vanderver   +9 more
wiley   +1 more source

Isotropic universe with almost scale-invariant fourth-order gravity

, 2013
We study a broad class of isotropic vacuum cosmologies in fourth-order gravity under the condition that the gravitational Lagrangian be scale-invariant or almost scale-invariant. The gravitational Lagrangians considered will be of the form L = f(R) + k(G)
Schmidt, H. -J., Singleton, D.
core   +1 more source

CX3CL1 in Early Detection of Alzheimer's Disease: Plasma Dynamics Across Age and Disease Stages

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Backgrounds Alzheimer's disease (AD) is characterized by amyloid‐beta plaques, tau tangles, and neuroinflammation. C‐X3‐C motif chemokine ligand 1 (CX3CL1, also known as fractalkine), a neuroimmune chemokine implicated in AD pathogenesis, shows inconsistent alterations in plasma/serum across studies.
Ling Wang, Yujie Liu, Fei Li, Xuelin Li, Lanlan Li, Jie Zhang, Yali Xu   +6 more
wiley   +1 more source

Riccati Technique and Asymptotic Behavior of Fourth-Order Advanced Differential Equations

Mathematics, 2020
In this paper, we deal with the oscillation of fourth-order nonlinear advanced differential equations of the form r t y ‴ t α ′ + p t f y ‴ t + q t g y σ t = 0 .
Omar Bazighifan, Ioannis Dassios
doaj   +1 more source

Fluid Biomarkers of Disease Burden and Cognitive Dysfunction in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Identifying objective biomarkers for progressive supranuclear palsy (PSP) is crucial to improving diagnosis and establishing clinical trial and treatment endpoints. This study evaluated fluid biomarkers in PSP versus controls and their associations with regional 18F‐PI‐2620 tau‐PET, clinical, and cognitive outcomes.
Roxane Dilcher, Charles B. Malpas, Stuart J. McDonald, William T. O’Brien, Craig Despott, Kelly L. Bertram, Matthew P. Pase, Lukas Frontzkowski, Meng Law, Terence J. O’Brien, Lucy Vivash   +10 more
wiley   +1 more source

On a fourth order superlinear elliptic problem

Electronic Journal of Differential Equations, 2001
We prove the existence of a nonzero solution for the fourth order elliptic equation $$Delta^2u= mu u +a(x)g(u)$$ with boundary conditions $u=Delta u=0$. Here, $mu$ is a real parameter, $g$ is superlinear both at zero and infinity and $a(x)$ changes sign ...
M. Ramos, P. Rodrigues
doaj