Results 51 to 60 of about 10,993,960 (288)

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source

The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection

Molecular Oncology, EarlyView.
Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński, Krzysztof Pastuszak, Anna Samelak‐Czajka, Zuzanna Cemka, Paulina Jackowiak, Tomasz Stefaniak, Sylwia Łapińska‐Szumczyk, Jacek Jassem, Anna J. Żaczek, Matthew T. Rondina, Myron G. Best, Sjors G. J. G. In 't Veld, Anna Supernat   +12 more
wiley   +1 more source

Envelope instability and the fourth order resonance

Physical Review Special Topics. Accelerators and Beams, 2014
The well-known envelope instability or the second order even collective mode [I. Hofmann, Phys. Rev. E 57, 4 (1998)] and the fourth order resonance 4σ=360° due to the nonlinear space charge effect in high intensity beams have been studied previously.
Chao Li, Ya Liang Zhao
doaj   +1 more source

Isoperimetric inequalities of the fourth order Neumann eigenvalues

Journal of Inequalities and Applications, 2020
In this paper, we obtain some isoperimetric inequalities for the first ( n − 1 ) $(n-1)$ eigenvalues of the fourth order Neumann Laplacian on bounded domains in an n-dimensional Euclidean space. Our result supports strongly the conjecture of Chasman.
Yanlin Deng, Feng Du
doaj   +1 more source

Overcoming platinum resistance by the disulfiram metabolite CuET in novel preclinical models of human carcinomas

Molecular Oncology, EarlyView.
Cisplatin‐resistant cancer cells survive DNA‐damaging platinum‐based treatment yet remain sensitive to CuET‐induced proteotoxic stress. The distinct mechanism of action allows CuET to overcome and eliminate cisplatin‐resistant tumour cells, unless highly expressed metallothioneins (MTs) interfere with CuET, thereby highlighting MT levels as candidate ...
Stefanos Arampatzis, Tereza Buchtová, Jirina Bartkova, Marie Lund Bay, Christoffer Lynge Halvorsen, Zuzana Machacova, Zdenek Skrott, Martin Mistrik, Ekaterina Dulina, Miguel Andujar‐Sanchez, Estrid Høgdall, Tine Henrichsen Schnack, Claus Høgdall, Berit Jul Mosgaard, Marie Boennelycke, Jacob Brink Laursen, Allan Jensen, Susanne K. Kjær, Tuula Kallunki, Robert Strauss, Jiri Bartek   +20 more
wiley   +1 more source

An outer membrane vesicle‐associated two‐track model for enterotoxigenic Bacteroides fragilis oncogenesis

Molecular Oncology, EarlyView.
Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi, Sang‐Hyeon Yoo, Ki‐Jong Rhee   +2 more
wiley   +1 more source

Multiplicity of solutions for some fourth-order m-point boundary-value problems

Electronic Journal of Differential Equations, 2010
Using the theory of the fixed point index in a cone and the Leray-Schauder degree, this paper investigates the existence and multiplicity of nontrivial solutions for a class of fourth order m-point boundary-value problems.
Haitao Li, Yansheng Liu
doaj  

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Fourth order, conservative discretization of horizontal Euler equations in the COSMO model and regional climate simulations

Meteorologische Zeitschrift, 2016
Horizontal spatial schemes of third order and above used for discretization of COSMO (Consortium for Small Scale Modeling) Euler equations can be described as quasi-higher order schemes since interpolation of the advecting velocities and differencing of ...
Jack Ogaja, Andreas Will
doaj   +1 more source

A high order numerical method for Ito stochastic Volterra integral equations [PDF]

Mathematics and Modeling in Finance
The main purpose of this paper is to propose a high order numerical method based on the finite difference methods for solving nonlinear Itˆo stochastic Volterra integral equations (SVIEs) of the second kind. To develop the method, a fourth-order implicit
Sadegh Amiri, Yasin Behrouzi
doaj   +1 more source