Results 101 to 110 of about 7,684 (200)

Foxl2 gene and the development of the ovary : a story about goat, mouse, fish and woman [PDF]

, 2005
In this review, we describe recent results concerning the genetics of sex determination in mammals. Particularly, we developed the study of the FOXL2 gene and its implication in genetic anomalies in goats (PIS mutation) and humans (BPES).
Baron, Daniel, Batista, Frank, Chaffaux, Stéphane, Cocquet, Julie, Cotinot, Corinne, Cribiu, Edmond, De Baere, Elfride, Fellous, Marc, Guiguen, Yann, Jaubert, Francis, Pailhoux, Eric, Pannetier, Maëlle, Vaiman, Daniel, Veitia, Reiner, Vigier, Bernard   +14 more
core   +4 more sources

Self‐Organizing Ovarian Somatic Organoids Preserve Cellular Heterogeneity and Reveal Cellular Contributions to Ovarian Aging

Aging Cell, Volume 25, Issue 1, January 2026.
We report the development and application of a mouse ovarian somatic organoid model to elucidate a fundamental new understanding of the cell biology of the aging ovarian microenvironment. ABSTRACT Ovarian somatic cells are essential for reproductive function, but no existing ex vivo models recapitulate the cellular heterogeneity or interactions within ...
Shweta S. Dipali, Aubrey Converse, Madison Q. Gowett, Pratik Kamat, Emily J. Zaniker, Abigail Fennell, Teresa Chou, Michele T. Pritchard, Mary Zelinski, Jude M. Phillip, Francesca E. Duncan   +10 more
wiley   +1 more source

Hypopituitarism in Patients with Blepharophimosis and FOXL2 Mutations.

Hormone research in paediatrics, 2020
FOXL2 is the gene involved in blepharophimosis, ptosis, and epicanthus inversus syndrome (BPES). There have been few single case reports of growth hormone deficiency (GHD) with this syndrome, and Foxl2 is known to be involved in pituitary development in mice.
Castets, Sarah, Roucher-Boulez, Florence, Saveanu, Alexandru, Mallet, Delphine, Chabre, Olivier, Amati-Bonneau, Patrizia, Bonneau, Dominique, Girardin, Celine, Morel, Yves, Villanueva, Carine, Brue, Thierry, Reynaud, Rachel, Nicolino, Marc   +12 more
openaire   +3 more sources

Juvenile Granulosa Cell Tumors of the Testis: A Clinicopathologic Study of 70 Cases with Emphasis on Its Wide Morphologic Spectrum [PDF]

, 2015
The clinical and pathologic features of 70 juvenile granulosa cell tumors (JGCTs) of the testis are presented. The patients were from 30 weeks gestational age to 10 years old; 60 of 67 (90%) whose ages are known to us were 6 months old or younger.
Cornejo, Kristine M., Kao, Chia-Sui, Ulbright, Thomas M., Young, Robert H.   +3 more
core   +1 more source

Microfilament‐Myosin II Regulates the Differentiation of Multinucleated Cysts into Oocytes and Influences Oocyte Developmental Potential in Mice

Advanced Science, Volume 12, Issue 45, December 4, 2025.
In this study, we provided new evidence identifying multinucleated cysts as precursors for oocyte differentiation. Within these cysts, organelles migrate and aggregate to form Balbiani body (B‐body) and establish early cellular polarity. Concurrently, excess nuclei are expelled, enabling cyst‐to‐oocyte differentiation. The microfilament‐myosin II plays
Rui Xu, Menghao Pan, Zhi Zheng, Yaju Tang, Yutong Yan, Sihai Lu, Sha Peng, Baohua Ma   +7 more
wiley   +1 more source

The developmental expression of foxl2 in the dogfish Scyliorhinus canicula [PDF]

Gene Expression Patterns, 2007
The FoxL2 genes are a subfamily of the Fox (forkhead box) gene family. FOXL2 is mutated in the disorder Blepharophimosis, Ptosis, and Epicanthus Inversus Syndrome (BPES), which is characterized by eyelid malformations, and Premature Ovarian Failure (POF).
Wotton, KR, French, KEM, Shimeld, SM
openaire   +3 more sources

Heat-induced masculinization in domesticated zebrafish is family-specific and yields a set of different gonadal transcriptomes [PDF]

, 2017
Understanding environmental influences on sex ratios is important for the study of the evolution of sex-determining mechanisms and for evaluating the effects of global warming and chemical pollution.
Francesc, Piferrer, Laia, Ribas, Liew, Woei C., Noelia, Díaz, Orbán, László, Rajini, Sreenivasan   +5 more
core   +1 more source

Minimizing Postoperative Scars in Epicanthoplasty: A Concise Review

Journal of Cosmetic Dermatology, Volume 24, Issue 12, December 2025.
ABSTRACT Background The epicanthal fold is a fibromuscular skin fold covering the medial aspect of the eye. Upper double eyelid blepharoplasty and epicanthoplasty have become the most frequently performed cosmetic surgeries in Asia. However, many surgeons have expressed concern for hypertrophic scarring following epicanthoplasty.
Fredrik A. Fineide, Richard C. Allen, Elin Bohman, Kim A. Tønseth, Tor P. Utheim, Ayyad Z. Khan   +5 more
wiley   +1 more source

HER2 and GATA4 are new prognostic factors for early-stage ovarian granulosa cell tumor-a long-term follow-up study [PDF]

, 2014
Peer ...
Andersson, Noora Karoliina, Anttonen, Mikko, Butzow, Ralf, Färkkilä, Anniina, Heikinheimo, Markku, Leminen, Arto, Unkila-Kallio, Leila   +6 more
core   +1 more source

Germ cell and other tumors in individuals with differences in sex development

CA: A Cancer Journal for Clinicians, Volume 75, Issue 6, Page 587-601, November/December 2025.
Abstract Approximately one in 3500 to one in 5100 live‐born infants have atypical external genital development, known as differences in sex development (DSD). In 2005, an expert consensus conference thoroughly reviewed aspects of health care for individuals with DSD.
Selma Feldman Witchel, Miguel Reyes‐Múgica   +1 more
wiley   +1 more source