Results 81 to 90 of about 5,621 (166)

FOXL2, GATA4, and SMAD3 interaction in the transcription complex.

, 2014
Both COS-7 and COV434 cells were transfected for 48 h. All cell lysates were immunoprecipitated using V5 epitope. A) COS-7 cells transfected with V5 tagged GATA4, V5 or GFP tagged wild type (WT) FOXL2 or SMAD3 overexpression vectors as indicated.
David L'Hôte (197958), Anniina Färkkilä (507681), Leila Unkila-Kallio (507682), Reiner A. Veitia (25135), Adrien Georges (201474), Markku Heikinheimo (68957), Sanna Vattulainen (507680), Mikko Anttonen (507677), Marjut Pihlajoki (507678), Noora Andersson (507679)   +9 more
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FOXL2 drives the differentiation of supporting gonadal cells in early ovarian development

Reproductive Biology and Endocrinology
Background Forkhead box L2 (FOXL2) is a transcription factor from the forkhead box family primarily expressed in the pituitary, ovaries, and eyelids. Human mutations in FOXL2 cause blepharophimosis, ptosis, epicanthus and inversus syndrome (BPES), which ...
Laura Danti, Karolina Lundin, Petra Nedeczey-Ruzsák, Timo Tuuri, Juha S. Tapanainen   +4 more
doaj   +1 more source

Gonadal transcriptome sequencing reveals sexual dimorphism in expression profiling of sex-related genes in Asian arowana (Scleropages formosus)

Frontiers in Genetics
Asia arowana (Scleropages formosus) is an ornamental fish with high economic value, while its sex determination mechanism is still poorly understood. By far, no morphological evidence or molecular marker has been developed for effective distinguishment ...
Chenxi Zhao, Chenxi Zhao, Chao Bian, Chao Bian, Xidong Mu, Xinhui Zhang, Xinhui Zhang, Qiong Shi, Qiong Shi, Qiong Shi   +9 more
doaj   +1 more source

FOXL2 functions in endometrial physiology in cattle

, 2017
L'implantation est une étape cruciale de la gestation et du développement post-natal chez les mammifères. L'implantation est définie comme l'établissement d'interactions cellulaires et permanentes entre un endomètre réceptif et un embryon compétent et ...
Lesage, Audrey
core  

Cloning, identification, and functional analysis of foxl2 gene and its expression after 17β‐estradiol (E2) treatment in Dabry’s sturgeon, Acipenser dabryanus

Frontiers in Marine Science
The study focuses on the critically endangered Dabry’s sturgeon (Acipenser dabryanus), a species on the brink of extinction in the wild. This research investigates the role of the Forkhead box protein L2 (foxl2) in the gonadal development and ...
Yacheng Hu, Yacheng Hu, Ruihua Tan, Tingting Shu, Tingting Shu, Zhong Chu, Haoran Wang, Yining Chen, Xin Zhu, Xin Zhu, Yang Li, Yang Li, Binzhong Wang, Binzhong Wang, Baifu Guo, Baifu Guo, Runqiu Wang, Runqiu Wang, Huantao Qu, Huantao Qu, Dezhi Zhang, Dezhi Zhang, Hejun Du, Hejun Du, Zhiyuan Li, Zhiyuan Li, Dan Xu, Wei Jiang, Wei Jiang, Qingfei Li, Yuanjin Yang, Yuanjin Yang   +31 more
doaj   +1 more source

Functional exploration of the adult ovarian granulosa cell tumor-associated somatic FOXL2 mutation p.Cys134Trp (c.402C>G).

PLoS ONE, 2010
BackgroundThe somatic mutation in the FOXL2 gene c.402C>G (p.Cys134Trp) has recently been identified in the vast majority of adult ovarian granulosa cell tumors (OGCTs) studied. In addition, this mutation seems to be specific to adult OGCTs and is likely
Bérénice A Benayoun, Sandrine Caburet, Aurélie Dipietromaria, Adrien Georges, Barbara D'Haene, P J Eswari Pandaranayaka, David L'Hôte, Anne-Laure Todeschini, Sankaran Krishnaswamy, Marc Fellous, Elfride De Baere, Reiner A Veitia   +11 more
doaj   +1 more source

Hypopituitarism in Patients with Blepharophimosis and FOXL2 Mutations

, 2020
International audienceBackground: FOXL2 is the gene involved in blepharophimosis, ptosis, and epicanthus inversus syndrome (BPES). There have been few single case reports of growth hormone deficiency (GHD) with this syndrome, and Foxl2 is known to be ...
Roucher-Boulez, Florence, Chabre, Olivier, Saveanu, Alexandru, Morel, Yves, Amati-Bonneau, Patrizia, Bonneau, Dominique, Nicolino, Marc, Brue, Thierry, Girardin, Celine, Villanueva, Carine, Reynaud, Rachel, Castets, Sarah, Mallet, Delphine   +12 more
core   +1 more source

Novel action of FOXL2 as mediator of Col1a2 gene autoregulation

, 2016
FOXL2 belongs to the evolutionarily conserved forkhead box (FOX) superfamily and is a master transcription factor in a spectrum of developmental pathways, including ovarian and eyelid development and bone, cartilage and uterine maturation. To analyse its
Marcia, Loredana, Cusano, Roberto, Deiana, Manila, Asunis, Isadora, Marongiu, Mara, Fotia, Giorgio, CUCCA, Francesco, Crisponi, Laura, Loi, Angela, Angius, Andrea, Schlessinger, David, Sbardellati, Andrea, Meloni, Alessandra, Crobu, Francesca   +13 more
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Wt FOXL2 reduces viable cell number, and GATA4 protects GCT cells from wt FOXL2 induced apoptosis.

, 2014
KGN cells were transfected with wild type FOXL2, C134W mutated FOXL2, GATA4, and SMAD3 expression plasmids. A) The cell viability was measured 48 h after transfection. B) The activated caspase 3/7 was measured 24 h after transfection.
David L'Hôte (197958), Anniina Färkkilä (507681), Leila Unkila-Kallio (507682), Reiner A. Veitia (25135), Adrien Georges (201474), Markku Heikinheimo (68957), Sanna Vattulainen (507680), Mikko Anttonen (507677), Marjut Pihlajoki (507678), Noora Andersson (507679)   +9 more
core   +1 more source

The proportion of FOXL2-positive cells in cancer stroma.

, 2018
The proportion of FOXL2-positive cells on each tissue section was scored using 5-tired scale and the results were plotted. High percentages of cancer stromal cells were FOXL2-positive in the ovary, whereas there were almost no FOXL2-positive cells ...
Aye Moh-Moh-Aung (5844032), Teizo Yoshimura (199118), Yoji Wani (5844035), Akihiro Matsukawa (197990), Masayoshi Fujisawa (5844029), Zheng Zeng (383660)   +5 more
core   +1 more source