Results 71 to 80 of about 5,621 (166)

Spatial Transcriptomic Atlas Reveals That Forkhead Box O3‐Mediated Mitochondrial Dynamics Imbalance Drives Premature Ovarian Insufficiency in Mice

Aging Cell, Volume 25, Issue 7, July 2026.
This study constructed a spatial transcriptomic atlas of POI mouse ovaries and confirmed that decreased FOXO3 phosphorylation triggers mitochondrial dynamic disorder, granulosa cell senescence and ovarian dysfunction. FOXO3‐mitochondrial axis is a shared core mechanism in both drug‐induced POI and physiological ovarian aging, offering promising ...
Ziwei Song, Yaoli Yin, Meilin Chen, Xiaolu Jin, Zemin Li, Hongxiao Li, Meihong Shen   +6 more
wiley   +1 more source

Effects of sexual steroids on the expression of foxl2 in Gobiocypris rarus

, 2011
Gobiocypris rams is an emerging fish model for aquatic toxicology in China as it is sensitive to environmental hormone disruptors. Exogenous sex steroids can affect sex differentiation and the expression of sex-related genes.
Zhao, HB (reprint author), Huazhong Normal Univ, Sch Life Sci, Hubei Key Lab Genet Regulat & Integrated Biol, Wuhan 430079, Hubei, Peoples R China, Duan, Jundan, Zhao, Dongmei, Yang, Yuhui, Liu, Xiaoyan, Jiang, Wenbo, Xie, Songguang, zhaohb@mail.ccnu.edu.cn, Zhao, Haobin   +8 more
core  

Sperm Sexing in Selected Animals and Humans: Methods, Applications, and Future Prospects

Andrology, Volume 14, Issue 5, Page 1089-1101, July 2026.
ABSTRACT Background Sperm sexing is a technique that enables the selection of offspring sex by sorting spermatozoa based on their sex chromosomes. This technology has gained increasing attention due to its potential applications in both animal breeding and human‐assisted reproduction.
Domrazek Kinga, Jurka Piotr
wiley   +1 more source

FOXL2 is a progesterone-regulated gene in ruminant endometrium

, 2014
National audienceImplantation is critical for pregnancy outcome and its progression relies on tightly coordinated interactions between the receptive endometrium and the developing embryo.
Eozenou, Caroline, Mauffré, Vincent, Sheldon, Iain Martin, Shimizu, T., Camous, Sylvaine, S., Constant, Fabienne, F., Sandra, Olivier, Healey, Gareth, Charpigny, Gilles, Miyamoto, Akio, Al Gubory, Kais Hussain, Pannetier, Maëlle, Lesage, Audrey   +12 more
core   +1 more source

Reference genome provide insights into sex determination of silver aworana (Osteoglossum bicirrhosum)

BMC Biology
Background Silver arowana (Osteoglossum bicirrhosum) is a basal fish species with sexual monomorphism, while its sex determination mechanism has been poorly understood, posing a significant challenge to its captive breeding efforts.
Yi Liu, Chao Bian, Ka Yan Ma, Yexin Yang, Yuanyuan Wang, Chao Liu, Guochang Ouyang, Meng Xu, Jinhui Sun, Changwei Shao, Jiehu Chen, Qiong Shi, Xidong Mu   +12 more
doaj   +1 more source

Chitosan-encapsulated linoleic acid from Leucaena leucocephala (Lam.) de Wit. inhibits FOXL2 mutation in MNU-induced ovarian granulosa cell tumors in Wistar rats

Next Nanotechnology
One of the biggest challenges in drug delivery is delivering drugs to their sites of action to avoid the systemic side effects that are common with most antineoplastic drugs.
Cletus Anes Ukwubile, Hassan Braimah Yesufu, Roland Nnaemeka Okoro, Ahamefula Anslem Ahuchaogu, Blessing Ogechukwu Umeokoli, Matthew Onyema Agu, Nnamdi David Menkiti, Patrick Akoji Ida   +7 more
doaj   +1 more source

Whole Exome Sequencing for Romanian Patients With Neurodevelopmental Disorders Through an International Collaboration

Clinical Genetics, Volume 110, Issue 1, Page 46-63, July 2026.
Whole exome sequencing for Romanian patients with neurodevelopmental disorders through an international collaboration—this study has provided a 50% diagnostic yield for patients with NDDs (27 positive results from 54 patients), supporting the implementation of a WES analysis that can identify SNVs, small INDELs, CNVs, and mitochondrial variants ...
Alexandru Caramizaru, Cristina Durac, Andreea Dumitrescu, Alexandru Calota‐Dobrescu, Alix de Becdelièvre, Marina Konyukh, Denise Cassandrini, Hane Lee, Go Hun Seo, Seung Woo Ryu, Mihai Cucu, Iuliana Manuela Dragomir, Andreea Catana, Homa Tajsharghi, Edoardo Malfatti, Florin Burada, Amelia Dobrescu   +16 more
wiley   +1 more source

Foxl2 regulation and function in gonadotropes

, 2013
Pituitary follicle-stimulating hormone (FSH) is crucial for mammalian reproduction; it regulates gametogenesis and gonadal function. We know that impaired FSH production may leads to infertility, yet the mechanisms controlling FSH synthesis are poorly ...
Tran, Stella Lê Minh
core  

Evolução e organização genômica do gene FOXL2 em vertebrados

, 2012
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Pós-graduação em Ciências Biológicas (Genética) - IBBFOXL2
Geraldo, Marcos Tadeu
core   +3 more sources

Sex Determination in Sponges

Molecular Reproduction and Development, Volume 93, Issue 6, June 2026.
ABSTRACT Sex determination in Porifera remains one of the least understood aspects of early metazoan biology despite the group's key phylogenetic position. Sponges display exceptional diversity in sexual systems—ranging from stable gonochorism to sequential hermaphroditism and sex reversal—yet lack morphological dimorphism and any discrete gonadal ...
Jose M. Lorente‐Sorolla, Ana Riesgo
wiley   +1 more source