Results 61 to 70 of about 5,621 (166)
Maximal expression of Foxl2 in pituitary gonadotropes requires ovarian hormones. [PDF]
PLoS ONE, 2015 Gonadotropin-releasing hormone (GnRH) and activin regulate synthesis of FSH and ultimately fertility. Recent in vivo studies cast SMAD4 and FOXL2 as master transcriptional mediators of activin signaling that act together and independently of GnRH to ...
Maria K Herndon, John H Nilson
doaj +1 more source
Ubiquitin and ubiquitin‐like modifications in the endoplasmic reticulum stress response
The FEBS Journal, Volume 293, Issue 18, Page 5481-5513, September 2026.Endoplasmic reticulum (ER) stress activates various proteostasis control processes, including the unfolded protein response, ribosome‐associated quality control, and ER‐associated degradation. Ubiquitin and ubiquitin‐like modifications dynamically regulate these processes to determine cell fate, promoting adaptation or inducing cell death.
Tony Avril +2 more
wiley +1 more source
Foxl2, a forkhead transcription factor, modulates nonclassical activity of the estrogen receptor-alpha [PDF]
, 2009 Foxl2 is a forkhead transcription factor required for ovary development and ovarian follicle maturation. In this report, we identified and characterized a functional relationship between Foxl2 expression and estrogen receptor (ER)-alpha signaling.
이은직
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Frontiers in Physiology, 2018 Exposure to stress induces a series of responses and influences a wide range of biological processes including sex differentiation in fish. The present work investigated the molecular and physiological response to thermal stress throughout the early ...
Zhi-Gang Shen +7 more
doaj +1 more source
Expression of ASMA and FAP by FOXL2-positive ovarian cells.
, 2018 (A-C) Tumor tissues were double stained for FOXL2 and ASMA or FAP. Nuclear FOXL2 was stained brown whereas cytoplasmic ASMA and FAP were stained red in B and C, respectively.
Aye Moh-Moh-Aung (5844032) +5 more
core +1 more source
The Journal of Pathology: Clinical Research, Volume 12, Issue 4, July 2026.Abstract Recurrent fusions involving FGFR1‐4 genes have been previously described in rare subsets of mostly benign chondroid and mesenchymal neoplasms involving bone and soft tissue. However, a more comprehensive analysis of sarcomas associated with FGFR fusions, including their incidence and histotypes, has not been performed.
Maximus CF Yeung +4 more
wiley +1 more source
Advanced Science, Volume 13, Issue 37, 3 July 2026.This study identifies a FOSL2‐driven positive feedback loop that amplifies FSH/FSHR signaling. During FSH‐dependent follicle maturation, FSH induces Fosl2 expression via the cAMP‐PKA‐CREB cascade. FOSL2 in turn binds the promoters of Fshr and estrogen‐biosynthesis genes to enhance their transcription, thereby increasing Fshr mRNA level and amplifying ...
Hongru Shi +13 more
wiley +1 more source
Modern competency‐based teaching of human sexual development
Anatomical Sciences Education, Volume 19, Issue 7, Page 1086-1096, July 2026.Abstract Embryology is an integral part of anatomy and a key subject in basic medical education. The development of the sexual tract, which is closely associated with the formation of the urinary tract and the organs of continence, is particularly complex and relevant for many medical disciplines.
Elisabeth Eppler +2 more
wiley +1 more source
The developmental expression of foxl2 in the dogfish Scyliorhinus canicula. [PDF]
, 2007 The FoxL2 genes are a subfamily of the Fox (forkhead box) gene family. FOXL2 is mutated in the disorder Blepharophimosis, Ptosis, and Epicanthus Inversus Syndrome (BPES), which is characterized by eyelid malformations, and Premature Ovarian Failure (POF).
KR Wotton (21860894) +2 more
core +4 more sources
Cancer Medicine, Volume 15, Issue 7, July 2026.ABSTRACT Genomic sequencing has made precision oncology of pancreatic ductal adenocarcinoma (PDAC) feasible and is recommended by numerous clinical guidelines. The clinical significance of genomic alterations in PDAC remains to be revealed. This study was designed to bridge this gap by elucidating the clinical relevance of genomic profiling in a ...
Mingwei Dong +11 more
wiley +1 more source