Results 91 to 100 of about 74,948 (336)

FoxO1 is a crucial mediator of TGF-β/TAK1 signaling and protects against osteoarthritis by maintaining articular cartilage homeostasis

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance Osteoarthritis (OA) is the most prevalent joint disease and has reached epidemic proportions in the United States. Currently, there are no effective therapeutic approaches to treat OA. Thus, there is an urgent need to develop mechanistically-
Cuicui Wang, Jie Shen, J. Ying, Ding Xiao, R. O’Keefe   +4 more
semanticscholar   +1 more source

BMSC-Derived Exosomes Inhibit Dexamethasone-Induced Muscle Atrophy via the miR-486-5p/FoxO1 Axis

Frontiers in Endocrinology, 2021
Sarcopenia, characterized by reduced muscle function as well as muscle mass, has been a public health problem with increasing prevalence. It might result from aging, injury, hormone imbalance and other catabolic conditions.
Ziyi Li, Chang Liu, Shilun Li, Ting Li, Yukun Li, Na Wang, Xiaoxue Bao, P. Xue, Sijing Liu   +8 more
semanticscholar   +1 more source

Targeting FoxO1 with AS1842856 Suppresses Adipogenesis [PDF]

Cell Cycle, 2014
Hyperplasia (i.e., increased adipogenesis) contributes to excess adiposity, the hallmark of obesity that can trigger metabolic complications. As FoxO1 has been implicated in adipogenic regulation, we investigated the kinetics of FoxO1 activation during adipocyte differentiation, and tested the effects of FoxO1 antagonist (AS1842856) on adipogenesis. We
Zou, Peng, Liu, Longhua, Zheng, Louise, Liu, Lu, Stoneman, Rebecca E., Cho, Alicia, Emery, Ashley, Gilbert, Elizabeth R., Cheng, Zhiyong   +8 more
openaire   +3 more sources

DNMT3B in vitro knocking-down is able to reverse embryonal rhabdomyosarcoma cell phenotype through inhibition of proliferation and induction of myogenic differentiation [PDF]

, 2016
Aberrant DNA methylation has been frequently observed in many human cancers, including rhabdomyosarcoma (RMS), the most common soft tissue sarcoma in children.
Camero, Simona, Ceccarelli, Simona, Clerico, Anna, Dominici, Carlo, Mannarino, Olga, Marampon, Francesco, Marchese, Cinzia, Mcdowell, Heather P, Megiorni, Francesca, Pizer, Barry, Pizzuti, Antonio, Shukla, Rajeev   +11 more
core   +1 more source

Baicalin ameliorates neuroinflammation-induced depressive-like behavior through inhibition of toll-like receptor 4 expression via the PI3K/AKT/FoxO1 pathway

Journal of Neuroinflammation, 2019
Baicalin, which is isolated from Radix Scutellariae, possesses strong biological activities including an anti-inflammation property. Recent studies have shown that the anti-inflammatory effect of baicalin is linked to toll-like receptor 4 (TLR4), which ...
Liting Guo, Si-Qi Wang, Jing Su, Lixing Xu, Zhouye Ji, Ru-yi Zhang, Qingyi Zhao, Zhan-qiang Ma, Xueyang Deng, Shiping Ma   +9 more
semanticscholar   +1 more source

IL1R2 Marks and Sorts a Spermatogonial Stem Cell Population Critical for Restoring Spermatogenesis Upon Interruption in Mammals

Advanced Science, EarlyView.
Spermatogonial stem cells (SSCs) provide critical support to spermatogenesis. Here, the author established Il1r2 as a sorting marker for SSCs, with which further insights into the SSC heterogeneity and dynamic features can be obtained. They also confirmed findings in both mouse and human, thus validating IL1R2 as the surface marker for isolating and ...
Pengyu Li, Zexuan Zhang, Zihan Xie, Cheng Jin, Zhipeng Wang, Changwei Yuan, Jun Zhu, Jielin Tang, Mengzhen Li, Dingfeng Zou, Xinyu Mang, Jun Liu, Dingyao Chen, Qi Geng, Yan Lu, Ning Zhang, Shiying Miao, Jing Peng, Kai Li, Wei Song   +19 more
wiley   +1 more source

Sirtuins 1–7 expression in human adipose-derived stem cells from subcutaneous and visceral fat depots: influence of obesity and hypoxia [PDF]

, 2016
The sirtuin family comprises seven NAD+-dependent deacetylases which control the overall health of organisms through the regulation of pleiotropic metabolic pathways.
Di Rocco, Giuliana, Mariani, Stefania, Petrangeli, Elisa, Russo, Matteo A., Salvatori, Luisa, Toietta, Gabriele   +5 more
core   +1 more source

Foxo1 controls gut homeostasis and commensalism by regulating mucus secretion

Journal of Experimental Medicine, 2021
The host-derived regulatory network that controls mucus secretion and thereby changes gut microbiota has not been fully illustrated. Here, we identify that Forkhead box protein O1 (Foxo1) is critical for gut commensalism and intestinal barrier integrity ...
Zuojia Chen, Jialie Luo, Jian Li, Girak Kim, E. Chen, S. Xiao, S. Snapper, B. Bao, Dingding An, R. Blumberg, Cheng-Hui Lin, Sui Wang, Jiaxin Zhong, Kuai Liu, Qiyuan Li, Chuan Wu, V. Kuchroo   +16 more
semanticscholar   +1 more source

Polymerase independent repression of FoxO1 transcription by sequence-specific PARP1 binding to FoxO1 promoter [PDF]

Cell Death & Disease, 2020
AbstractPoly(ADP-ribose) polymerase 1 (PARP1) regulates gene transcription in addition to functioning as a DNA repair factor. Forkhead box O1 (FoxO1) is a transcription factor involved in extensive biological processes. Here, we report that PARP1 binds to two separate motifs on the FoxO1 promoter and represses its transcription in a polymerase ...
Tian, Yu-Nan, Chen, Hua-Dong, Tian, Chang-Qing, Wang, Ying-Qing, Miao, Ze-Hong   +4 more
openaire   +4 more sources

PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC

Advanced Science, EarlyView.
CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy,
Zheyu Shao, Qinyuan Liu, Zhongwei Xin, Zhiyao Zhou, Mingjie Lin, Di Chen, Zhixing Hao, Yongyuan Chen, Wenxuan Wu, Shuyang Zhang, Xiaoke Chen, Xia Xu, Jinfan Li, Wei Lin, Yuhao Lu, Dang Wu, Pin Wu   +16 more
wiley   +1 more source