Central obesity and dyslipidaemia converge to impair insulin signalling and trigger chronic inflammation, oxidative stress, and mitochondrial dysfunction. This integrated metabolic disruption drives lipid imbalance, apoptosis, and persistent hyperglycaemia, ultimately accelerating the progression of type 2 diabetes and cardiovascular disease.
Muhammad Reva Aditya +11 more
wiley +1 more source
Miao Sour Soup Modulates Hepatic Gluconeogenesis Through PI3K/Akt/Foxo1 Signaling in High-Fat Diet-Induced Rats. [PDF]
Ao X +6 more
europepmc +1 more source
Embryonic Mediators of Embryo–Uterus Communication, Implantation and Pregnancy
ABSTRACT Successful reproduction in eutherian mammals requires intimate connections between the embryo and uterus, involving adhesion, attachment and placentation, with or without invasion of the endometrium. The complex dialogue between embryo and uterus involves numerous molecules and pathways.
Keith E. Latham
wiley +1 more source
Mechanism of FoxO1 in the Metabolic Shift of Fetal Rat Heart. [PDF]
William W +5 more
europepmc +1 more source
Ammonia Metabolism in the Aging Liver: Emerging Mechanistic Insights
Liver aging may weaken ammonia‐detoxification reserve by disrupting mitochondrial ureagenesis, GS‐mediated scavenging, glutamine metabolism, and metabolic zonation. This emerging framework links impaired nitrogen handling to potential hepatic stress amplification and systemic crosstalk, while highlighting the need for direct validation in physiological
Heng Zhang, Guangyu Liang, Anding Liu
wiley +1 more source
FOXO1-mediated cell cycle arrest enhances osteogenic differentiation of spheroid-cultured human periodontal ligament-derived multipotent mesenchymal stromal cells. [PDF]
Hironaka S +9 more
europepmc +1 more source
Alpha‐crystallin B chain (CRYAB) has been reported to stabilize mothers against decapentaplegic homolog 4 (SMAD4) in transforming growth factor‐β (TGF‐β) signaling, enabling target gene transcription. We show nuclear CRYAB–SMAD4 interaction for the first time in human skeletal muscle fibers and its regulation by exercise.
Kirill Schaaf +7 more
wiley +1 more source
Ulinastatin attenuates capillary leakage and suppresses FoxO1-dependent angiopoietin-2 in sepsis-associated acute lung injury via PI3K pathway. [PDF]
Lv Y +14 more
europepmc +1 more source
A Genomic and Epigenetic Comparative Study of Low-grade Biphenotypic Sinonasal Sarcoma with Metachronous and Synchronous High-grade Rhabdomyosarcomatous Transformation. [PDF]
Sibira RM +10 more
europepmc +1 more source

