Results 131 to 140 of about 38,355 (234)

Obesity Disrupts CtBP2‐Mediated Maintenance of Transcriptional Equilibrium in Hypothalamic Feeding Circuitry

The FASEB Journal, Volume 40, Issue 15, 15 August 2026.
CtBP2, a transcriptional corepressor with metabolite sensing capabilities, maintains feeding homeostasis by preventing excessive food intake in the hypothalamic feeding center. CtBP2 limits food intake by inhibiting KLF4 within AgRP neurons and by promoting the inhibitory influence of POMC neurons on AgRP neurons.
Wanpei Chen, Kenta Kainoh, Kenji Saito, Takaaki Matsuda, Daichi Yamazaki, Yuto Kobari, Ayumi Nakata, Nao Aono‐Soma, Takafumi Miyamoto, Yuki Murayama, Yoko Sugano, Yoshinori Osaki, Hitoshi Iwasaki, Takashi Matsuzaka, Hitoshi Shimano, Motohiro Sekiya   +15 more
wiley   +1 more source

FOXO1 or not FOXO1: that is the question

Cancer Communications
Maude Marchais, Marianne Mangeney
openaire   +3 more sources

Modification of the Transcription Factor FOXL2 at Serines 101 and 107 Disables DNA Binding, Leads to Nucleolar Relocalization, and Rewires Granulosa‐Cell Programs

The FASEB Journal, Volume 40, Issue 15, 15 August 2026.
PKC‐mediated phosphorylation of FOXL2 weakens DNA binding, alters subnuclear localization and protein interactions, and reshapes FOXL2‐dependent transcriptional programs in granulosa cells, supporting a reversible mechanism that modulates FOXL2 activity through phosphorylation of its DNA‐binding domain. ABSTRACT FOXL2 is a forkhead transcription factor
Ludovic Mousseron, Despoina Chousianiti, Francis Poulat, Bérangère Legois, Reiner A. Veitia, Anne‐Laure Todeschini   +5 more
wiley   +1 more source

Gut Microbiota, Immunity, and Metabolism in the Progression From Chronic Liver Disease to Hepatocellular Carcinoma

Advanced Science, Volume 13, Issue 44, 7 August 2026.
This review explains how chronic liver injury progresses toward hepatocellular carcinoma through interconnected changes in gut microbes, metabolism, immunity, fibrosis, and diet. It highlights microbial metabolites, bile‐acid signaling, immune dysfunction, and nutritional or microbiome‐based interventions as opportunities to identify risk earlier ...
Yi Hu, Caiyan Lin, Lijie Zhang, Xue Jiang, Huawen Li, Yangzhe Wu   +5 more
wiley   +1 more source

Autophagy, FOXO1 and proteostasis

, 2012
Cellen maken niet alleen voortdurend nieuwe eiwitten en bouwen steeds nieuwe structuren, maar moeten ook steeds delen kunnen afbreken, recyclen en afvoeren. Autofagie is een mechanisme dat cellen in staat stelt om onbruikbare of beschadigde cellulaire componenten af te breken.
openaire   +1 more source

MicroRNAs in Spinal Cord Injury: Molecular and Translational Insights

Brain and Behavior, Volume 16, Issue 8, August 2026.
MicroRNAs (miRNAs) modulate secondary injury cascades following spinal cord injury (SCI), including inflammation, oxidative stress, apoptosis, and demyelination. Key miRNAs such as miR‐21, miR‐124, miR‐219, and miR‐223 exert neuroprotective effects by regulating astrocytic response, axon regeneration, and remyelination.
Seyyedeh Fahimeh Talebi, Hossein Kalarestaghi, Ehsan Sheikh Hesabi, Saeed Vafaei‐Nezhad   +3 more
wiley   +1 more source

Selected monosaccharides in cancer: Metabolic routing, post‐translational modification, immunity and therapeutic potential

Clinical and Translational Discovery, Volume 6, Issue 4, August 2026.
Glucose, galactose, mannose and fructose can either fuel or fight tumours by rewiring metabolism and immunity. Their context‐dependent double‐edged nature suggests that precisely targeted monosaccharide interventions could become a new pillar of precision oncology.
Qin Ouyang, Ke Gao, Haojie Lu, Shu Zhang
wiley   +1 more source

3,3′,4,5′‐Tetramethoxy‐trans‐stilbene Alleviates Metabolic Dysfunction‐Associated Steatotic Liver Disease

eFood, Volume 7, Issue 4, August 2026.
3,3′,4,5′‐Tetramethoxy‐trans‐stilbene alleviates hepatic insulin resistance and metabolic dysfunction‐associated steatotic liver disease, through the activation of IRS/PI3K/Akt/GSK3β/GS and Nrf2/HO‐1 pathways, in diet‐induced obese mice. The figure was created with MedPeer (medpeer.cn).
Qiaowen Deng, Yuehan Wang, Feiyang Zheng, Manqin Fu, Chumin Zhong, Dharmani Devi Murugan, Wai San Cheang   +6 more
wiley   +1 more source

FOXO family and neurodegenerative diseases: Mechanisms of action and therapeutic potential. [PDF]

Redox Biol
Lv Z, Liu X, Zhou Z, Huang Q, Liu H, Xu Z, Xu P.   +6 more
europepmc   +1 more source

Myocardial Lipid Metabolism Imbalance: The Pathological Core and Novel Diagnostic‐Therapeutic Directions of Cardiovascular Diseases

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
In cardiac cells, Plin5/AMPK regulate lipid homeostasis; excess CD36‐mediated uptake drives lipotoxicity, mitochondrial dysfunction, and CVDs (e.g., heart failure). Biomarkers (ApoB/ApoA‐1) and therapies (SGLT2 inhibitors) target this cascade. ABSTRACT Cardiac lipid metabolism is fundamental to myocardial energy homeostasis, with fatty acid oxidation ...
Peiyun Xie, Qun Zeng, Hongrui Wang, Meihua She   +3 more
wiley   +1 more source