Results 241 to 250 of about 74,948 (336)

FOXO1 Inhibition and FADD Knockdown Have Opposing Effects on Anticancer Drug-Induced Cytotoxicity and p21 Expression in Osteosarcoma Cells. [PDF]

Int J Mol Sci
Walker D, Hall A, Bonwell A, Gordon N, Robinson D, Hollomon MG.   +5 more
europepmc   +1 more source

Author response: Endothelial-specific FoxO1 depletion prevents obesity-related disorders by increasing vascular metabolism and growth

, 2018
Martina Rudnicki, Ghoncheh Abdifarkosh, Emmanuel Nwadozi, Sofhia V. Ramos, Armin Makki, Diane M. Sepa-Kishi, Rolando B. Ceddia, Christopher G. R. Perry, Emilie Roudier, Tara L. Haas   +9 more
openalex   +1 more source

T Cell Exhaustion in Hepatocellular Carcinoma: A Substantial Barrier in Immunotherapy

Journal of Cellular and Molecular Medicine, Volume 30, Issue 3, February 2026.
ABSTRACT Hepatocellular carcinoma (HCC), accounting for over 90% of primary liver cancers, remains a major global challenge for healthcare professionals. While immunotherapy has transformed the landscape of cancer treatment, its success is often limited by immune resistance, particularly through T cell exhaustion which remains a major barrier to ...
Kosar Nouri, Negar Asadollahei, Yasamin Haghir‐Sharif‐Zamini, Homeyra Seydi, Mahsa Salehi, Mehrnaz Mesdaghi, Mustapha Najimi, Massoud Vosough   +7 more
wiley   +1 more source

The high protein expression of FOXO3, but not that of FOXO1, is associated with markers of good prognosis [PDF]

, 2020
François Lallemand, Sophie Vacher, Leanne de Koning, Ambre Petitalot, Adrien Briaux, Keltouma Driouch, Céline Callens, Anne Schnitzler, Caroline Lecerf, Floriane Oulie-Bard, Aurélie Barbet, Anne Vincent, Sophie Zinn‐Justin, Bernard S. López, Rosette Lidereau, Ivan Bièche, Sandrine M. Caputo   +16 more
openalex   +1 more source

Using an Unbiased Coexpression Network to Reveal Cross‐Talking Pathways of Phosphoinositide‐3‐Kinase Regulatory Subunit 1 in Skin Aging and Rejuvenation

The FASEB Journal, Volume 40, Issue 2, 31 January 2026.
Mechanistic pathways of PIK3R1 in skin aging and rejuvenation were analyzed by bioinformatics approach and Gene Expression Omnibus database. Compared with young skin, PIK3R1 was differentially expressed in aged and IPL rejuvenated skin. Coexpression and network analyses revealed that PIK3R1 jointly participated in skin aging and rejuvenation via PI3K ...
Zhike Zhou, Sha Sha, Xiangnan Zhou, Chundi He, Ting Xiao, Yan Wu, Fenqin Chen, Le Qu, Hong‐Duo Chen   +8 more
wiley   +1 more source

Comprehensive Analysis of FOXO1 as a Tumour Suppressor Biomarker Related to Immune Infiltration and Cell Proliferation of Hepatocellular Carcinoma. [PDF]

IET Syst Biol
Xia S, Qin X, Pan C, Fan D, Yang D.
europepmc   +1 more source

Additional file 2 of Study of FOXO1/pFOXO1, lncRNA ADAMTS9-AS2, and miR-96-5p in laryngeal squamous cell carcinoma

Masoomeh Bakhshandeh, Payam Mohammadi, Najmeh Parvaz, Maryam Lotfi, Omid Joodi, Mohammad Najafi   +5 more
openalex   +1 more source

Maternal Fructose Intake During Pregnancy Induced the Hepatic Glucose Homeostasis Imbalance in the Offspring by Inhibiting Glucokinase

The FASEB Journal, Volume 40, Issue 2, 31 January 2026.
Schematic diagram of the core mechanisms. The study demonstrated that maternal fructose intake during pregnancy led to glucose intolerance and insulin resistance in offspring. The abnormal hepatic glucose metabolism in offspring was associated with decreased GK expression, which was inhibited by DNMT3B.
Yahui Miao, Ziyu Meng, Shihang Chen, Xiaoyu Li, Ting Fang, Xiaoqing Deng, Bei Sun, Liming Chen   +7 more
wiley   +1 more source

Dual-specificity phosphatase 6 interferes with the repressive activity of forkhead box O1 towards CYP4A11 that mediates lipid accumulation in the liver. [PDF]

Sci Rep
Kimura M, Saiki Y, Iwata K, Murakami K, Furukawa T.   +4 more
europepmc   +1 more source

Persimmon carotenoid extract rich in β‐cryptoxanthin improves glucose homeostasis and reduces liver damage in high‐fat‐diet‐induced type 2 diabetic and metabolic dysfunction‐associated steatotic liver disease mice

Journal of the Science of Food and Agriculture, Volume 106, Issue 2, Page 1299-1313, 30 January 2026.
Abstract Background Persimmon (Diospyros kaki Thunb.) byproducts are a remarkable source of bioactive compounds, particularly carotenoids. Several studies suggest that carotenoids have beneficial effects in prevention of a large number of diseases. This study aims to highlight the effects of a persimmon carotenoid extract (PSCE) rich in β‐cryptoxanthin
Bryan Moreno‐Chamba, Nuria Martí, Antonio Cárdenas, María Soledad Fernández‐Pachón, Blanca Escudero‐López, Franz Martín, Julio Salazar‐Bermeo, Manuel Valero, Domingo Saura, María Concepción Martínez‐Madrid, Genoveva Berná   +10 more
wiley   +1 more source