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American Journal of Physiology. Endocrinology and Metabolism, 2023
Skeletal muscle atrophy is often found in patients with type 2 diabetes mellitus (T2DM) which is characterized with insulin resistance. As the largest tissue in the body, skeletal muscle plays important roles in insulin resistance. Advanced glycation end
Haixia Du +7 more
semanticscholar +1 more source
Skeletal muscle atrophy is often found in patients with type 2 diabetes mellitus (T2DM) which is characterized with insulin resistance. As the largest tissue in the body, skeletal muscle plays important roles in insulin resistance. Advanced glycation end
Haixia Du +7 more
semanticscholar +1 more source
The FASEB Journal, 2022
Catabolic conditions, such as starvation, inactivity, and cancer cachexia, induce Forkhead box O (FOXO) transcription factor(s) expression and severe muscle atrophy via the induction of ubiquitin–proteasome system‐mediated muscle proteolysis, resulting ...
Mamoru Oyabu +13 more
semanticscholar +1 more source
Catabolic conditions, such as starvation, inactivity, and cancer cachexia, induce Forkhead box O (FOXO) transcription factor(s) expression and severe muscle atrophy via the induction of ubiquitin–proteasome system‐mediated muscle proteolysis, resulting ...
Mamoru Oyabu +13 more
semanticscholar +1 more source
Targeting FoxO1 for Hypertriglyceridemia
Current Drug Targets, 2011Hypertriglyceridemia is characterized by increased production and decreased clearance of triglyceride-rich lipoproteins including very low-density lipoprotein (VLDL) and chylomicron. Due to its proatherogenic profile, hypertriglyceridemia contributes to the development of atherosclerosis and coronary artery disease.
Dae Hyun, Kim +3 more
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miR-139 impacts FoxO1 action by decreasing FoxO1 protein in mouse hepatocytes
Biochemical and Biophysical Research Communications, 2009FoxO1 is a master regulator of signaling pathways used by growth factors and hormones, including insulin. Its activity is regulated by changes in subcellular localization coupled to post-translational modifications such as phosphorylation, ubiquitination, and acetylation.
Larbi Kamal, Hasseine +5 more
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Journal of Zhejiang University-SCIENCE B, 2023
To explore the role of forkhead box protein O1 (FOXO1) in the progression of glioblastoma multiforme (GBM) and related drug resistance, we deciphered the roles of FOXO1 and miR-506 in proliferation, apoptosis, migration, invasion, autophagy, and temozolomide (TMZ) sensitivity in the U251 cell line using in vitro and in vivo experiments.
Chao Chen +5 more
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To explore the role of forkhead box protein O1 (FOXO1) in the progression of glioblastoma multiforme (GBM) and related drug resistance, we deciphered the roles of FOXO1 and miR-506 in proliferation, apoptosis, migration, invasion, autophagy, and temozolomide (TMZ) sensitivity in the U251 cell line using in vitro and in vivo experiments.
Chao Chen +5 more
openaire +2 more sources
Foxo1 Corepressor (FCoR) and Foxo1 Regulate a-Cell and ß-Cell Identity
Diabetes, 2018We previously identified a Foxo1 binding protein; Foxo1 CoRepressor (FCoR), in adipocytes. FCoR inhibits Foxo1 activity by enhancing its acetylation. FCoR is expressed in pancreatic α- and β-cells from the embryonic stage. Fcor knockout mice (FcorKO) show impaired glucose tolerance, decreased insulin secretion, increased glucagon secretion and ...
NORIKO KODANI, JUN NAKAE, HIROSHI ITOH
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FOXO1/3: Potential suppressors of fibrosis
Ageing Research Reviews, 2018Fibrosis is a universally age-related disease that involves nearly all organs. It is typically initiated by organic injury and eventually results in organ failure. There are still few effective therapeutic strategy targets for fibrogenesis. Forkhead box proteins O1 and O3 (FOXO1/3) have been shown to have favorable inhibitory effects on fibroblast ...
Zhenlong, Xin +8 more
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