Results 61 to 70 of about 74,948 (336)

Comparative Analysis of Muscle Transcriptome between Pig Genotypes Identifies Genes and Regulatory Mechanisms Associated to Growth, Fatness and Metabolism. [PDF]

, 2015
Iberian ham production includes both purebred (IB) and Duroc-crossbred (IBxDU) Iberian pigs, which show important differences in meat quality and production traits, such as muscle growth and fatness.
Ayuso, Miriam, Barragán, Carmen, Benítez, Rita, Cánovas, Ángela, Fernández, Almudena, Fernández, Ana Isabel, González-Bulnes, Antonio, Isabel, Beatriz, López-Bote, Clemente, Medrano, Juan F, Núñez, Yolanda, Ovilo, Cristina, Rey, Ana Isabel   +12 more
core   +4 more sources

The transcription factor Foxo1 controls germinal center B cell proliferation in response to T cell help [PDF]

, 2017
Germinal center (GC) B cells cycle between two states, the light zone (LZ) and the dark zone (DZ), and in the latter they proliferate and hypermutate their immunoglobulin genes. How this functional transition takes place is still controversial.
Allen, Bannard, Bonifaz, Boscardin, Calado, Chambers, Chie Kawai, Dansen, De Silva, Dominguez-Sola, Dominguez-Sola, Dorsey, Draghi, Dubrovska, Gitlin, Gitlin, Gong, Hedrick, Huang, Inoue, Ise, Itano, Kitamura, Kurosaki, Kuwahara, Liu, Murphy, Murphy, Paik, Pape, Rickert, Ryo Shinnakasu, Safford, Sagardoy, Sander, Schwickert, Shih, Shinnakasu, Shlomchik, Subramanian, Takeshi Egawa, Takeshi Inoue, Taylor, Toellner, Tomohiro Kurosaki, Trinh, Victora, Victora, Victora, Victora, Wataru Ise, Zhang, Zheng   +52 more
core   +2 more sources

FOXO1 promotes tumor progression by increased M2 macrophage infiltration in esophageal squamous cell carcinoma

Theranostics, 2020
Objective: The transcription factor forkhead box protein O1 (FOXO1) is critical for regulating cytokine and chemokine secretion. However, its function in the tumor microenvironment (TME) remains largely unexplored.
Ying Wang, Zhaojie Lyu, Yanru Qin, Xia Wang, Liangzhang Sun, Yu Zhang, Lanqi Gong, Shayi Wu, Shuo Han, Ying Tang, Yong-xu Jia, D. Kwong, N. Kam, X. Guan   +13 more
semanticscholar   +1 more source

DYRK1A regulates B cell acute lymphoblastic leukemia through phosphorylation of FOXO1 and STAT3.

Journal of Clinical Investigation, 2021
DYRK1A is a serine/threonine kinase encoded on human chromosome 21 (HSA21) that has been implicated in several pathologies of Down syndrome (DS), including cognitive deficits and Alzheimer's disease.
R. Bhansali, Malini Rammohan, Paul Lee, Anouchka P. Laurent, Q. Wen, P. Suraneni, B. Yip, Y. Tsai, S. Jenni, B. Bornhauser, Aurélie Siret, Corinne Fruit, Alexandra Pacheco-Benichou, E. Harris, Thierry Besson, B. Thompson, Y. Goo, N. Hijiya, M. Vilenchik, S. Izraeli, J. Bourquin, Sébastien Malinge, J. Crispino   +22 more
semanticscholar   +1 more source

Aging Reshapes γ/δ T-Cell Immunity Through a Type I Interferon-Foxo1 Axis. [PDF]

Aging Cell
Aging reshapes the peripheral γ/δ T‐cell compartment by promoting the expansion and enhanced IL‐17–driven activity of innate‐like γ/δ T cells in secondary lymphoid organs. This remodeling is controlled by type I interferon–dependent downregulation of Foxo1, linking aging to heightened pro‐inflammatory γ/δ T‐cell responses.
Durand A, Porte S, Xing E, Wu C, Le Bon A, Auffray C, Lucas B, Martin B.   +7 more
europepmc   +2 more sources

Metformin as a Therapeutic Target in Endometrial Cancers. [PDF]

, 2018
Endometrial cancer is the most common gynecologic malignancy in developed countries. Its increasing incidence is thought to be related in part to the rise of metabolic syndrome, which has been shown to be a risk factor for the development of ...
Johnson, Jennifer, Kim, Christine H., Lee, Teresa, Martinez-Outshoorn, Ubaldo E., Richard, Scott D., Rosenblum, Norman G., Schilder, Russell J.   +6 more
core   +2 more sources

Identification of entacapone as a chemical inhibitor of FTO mediating metabolic regulation through FOXO1

Science Translational Medicine, 2019
Entacapone improves metabolic homeostasis in diet-induced obese mice through a direct effect on an FTO-FOXO1 regulatory axis. The skinny on FTO Although the fat mass and obesity-associated gene FTO has been linked to genetic risk of obesity, the mRNA ...
S. Peng, Wen Xiao, Dapeng Ju, Baofa Sun, Nannan Hou, Qianlan Liu, Yanlin Wang, Haijiao Zhao, Chunchun Gao, Song Zhang, R. Cao, Pengfei Li, Huanwei Huang, Yongfen Ma, Yankai Wang, Weiyi Lai, Zhixiong Ma, Wei Zhang, Song Huang, Hailin Wang, Zhiyuan Zhang, Liping Zhao, T. Cai, Yong‐Liang Zhao, Fengchao Wang, Y. Nie, G. Zhi, Yun-Gui Yang, E. E. Zhang, N. Huang   +29 more
semanticscholar   +1 more source

Repression of glucocorticoid-stimulated angiopoietin-like 4 gene transcription by insulin. [PDF]

, 2014
Angiopoietin-like 4 (Angptl4) is a glucocorticoid receptor (GR) primary target gene in hepatocytes and adipocytes. It encodes a secreted protein that inhibits extracellular LPL and promotes adipocyte lipolysis.
Chen, Tzu-Chieh, Ching, Cecilia, Foo, Fritz, Kuo, Taiyi, McQueen, Allison, Wang, Jen-Chywan, Yan, Stephanie   +6 more
core   +1 more source

KLF5 Is Induced by FOXO1 and Causes Oxidative Stress and Diabetic Cardiomyopathy.

Circulation Research, 2020
RATIONALE Diabetic cardiomyopathy (DbCM) is a major complication in type-1 diabetes, accompanied by altered cardiac energetics, impaired mitochondrial function, and oxidative stress.
I. Kyriazis, Matthew Hoffman, Lea Gaignebet, A. Lucchese, Eftychia Markopoulou, D. Palioura, Chao Wang, T. Bannister, M. Christofidou-Solomidou, S. Oka, J. Sadoshima, W. Koch, I. Goldberg, V. Yang, A. Bialkowska, G. Kararigas, Konstantinos Drosatos   +16 more
semanticscholar   +1 more source

Targeting KDM4 for treating PAX3-FOXO1–driven alveolar rhabdomyosarcoma

Science Translational Medicine, 2022
Chimeric transcription factors drive lineage-specific oncogenesis but are notoriously difficult to target. Alveolar rhabdomyosarcoma (RMS) is an aggressive childhood soft tissue sarcoma transformed by the pathognomonic Paired Box 3–Forkhead Box O1 (PAX3 ...
Shivendra V. Singh, A. Abu-Zaid, Hongjian Jin, Jie Fang, Qiong Wu, Tingting Wang, H. Feng, Waise Quarni, Ying Shao, Lily A Maxham, A. Abdolvahabi, M. Yun, S. Vaithiyalingam, Haiyan Tan, J. Bowling, Victoria Honnell, B. Young, Yian Guo, R. Bajpai, S. Pruett-Miller, G. Grosveld, M. Hatley, Beisi Xu, Yiping Fan, Gang Wu, E. Chen, Taosheng Chen, P. Lewis, Z. Rankovic, Yimei Li, A. Murphy, J. Easton, Junmin Peng, Xiang Chen, Ruoning Wang, S. White, A. Davidoff, Jun Yang   +37 more
semanticscholar   +1 more source