Results 311 to 320 of about 171,978 (359)
Tregs epigenetically reprogrammed from autoreactive effector T cells mitigate established autoimmunity. [PDF]
JCI InsightColson TR +7 more
europepmc +1 more source
Hybrid regulatory T cells: camouflaged architects of tumor immunity. [PDF]
Front ImmunolAzimnasab-Sorkhabi P +3 more
europepmc +1 more source
Nature Immunology, 2017 By switching its partners, FoxP3 segregates into functional and non-functional transcriptional complexes.
David Bending, Masahiro Ono
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The regulation of immune tolerance by FOXP3 [PDF]
Nature Reviews Immunology, 2017 The proper restraint of the destructive potential of the immune system is essential for maintaining health. Regulatory T (Treg) cells ensure immune homeostasis through their defining ability to suppress the activation and function of other leukocytes.
Ling Lu, Joseph Barbi, Fan Pan
exaly +4 more sources
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Polymorphism of the ovine FOXP3 gene (FOXP3)
Veterinary Immunology and Immunopathology, 2011FOXP3 is a transcription factor predominantly expressed in CD4(+) CD25(+) thymocytes and CD4(+) CD25(+) peripheral T cells. It has been reported that variation in the FOXP3 gene (FOXP3) could cause impaired immune regulation. Using PCR-SSCP, variation in exon 4, exon 9-10 and exon 13-14 of ovine FOXP3, covering three functional domains (a proline rich ...
Jon G.H. Hickford +2 more
openaire +3 more sources
Annals of the New York Academy of Sciences, 2008
Tolerance to self antigens is established in two ways: first in the thymus through the deletion of thymocytes expressing self‐reactive T cell receptors; and second, in the periphery through multiple mechanisms involving deletion, anergy, and suppression.
Steven F. Ziegler, Jane H. Buckner
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Tolerance to self antigens is established in two ways: first in the thymus through the deletion of thymocytes expressing self‐reactive T cell receptors; and second, in the periphery through multiple mechanisms involving deletion, anergy, and suppression.
Steven F. Ziegler, Jane H. Buckner
openaire +2 more sources
Role of Activin A in the Induction of Foxp3+ and Foxp3− CD4+ Regulatory T Cells
Critical Reviews™ in Immunology, 2011Regulatory T cells (Tregs) play a crucial role in the maintenance of immune homeostasis. The two best studied types of CD4(+) regulatory T cells are the Foxp3(+) Tregs and the T regulatory type 1 (Tr1) cells. CD4(+) regulatory T cells play a protective role in autoimmune disease. On the other hand, they also may have pathogenic properties in infectious
Christoph Schramm, Samuel Huber
openaire +3 more sources