Targeted Intracellular Copper Reservoir Enhances Liver Cancer Immunotherapy
Sono‐activatable TPEN‐encapsulated cancer‐targeted nanoparticles (STCNs) with sonodynamic therapy (SDT)‐amplified immunotherapeutic properties for liver cancer treatment via endogenous cuproptosis are developed. STCNs can effectively treat liver cancer through endogenous cuproptosis by TPEN and ROS generated by SDT, resulting in increased immune ...
Tianao Xie+15 more
wiley +1 more source
Influences of metabolism and lipid homeostasis on regulatory vs. conventional T cells and implications for autoimmunity. [PDF]
Nguyen MA, Lee SS, Walsh CM.
europepmc +1 more source
Dissecting Microscopic Colitis Immunopathophysiology: Insights From Basic Research
ABSTRACT Microscopic colitis is an inflammatory bowel disease (IBD) comprising two clinically undiscernible entities: collagenous colitis and lymphocytic colitis. Collagenous colitis associates with HLA genes and displays a Th1/Tc1–Th17/Tc17 profile with pericryptal myofibroblast activity, water malabsorption and secondary fluid loss due to altered ...
Andreas Münch+1 more
wiley +1 more source
Regulatory T Cells Control Vascular Adhesion Molecule Expression in Skin Under Inflammatory and Homeostatic Conditions. [PDF]
Norman MU+5 more
europepmc +1 more source
The regulatory effects and applications of TIGIT/CD155 on the tumor microenvironment in HCC
Background The interaction between TIGIT and CD155 compromises immune cell efficacy in tumor targeting, potentially driving hepatocellular carcinoma (HCC) progression through diverse molecular pathways. What Was Done This study investigates the interplay between CD155 and TIGIT in regulating CD8+ T cell function and elucidates its implications in HCC ...
Wenting Li+10 more
wiley +1 more source
The Spatial Proximity of CD8<sup>+</sup> FoxP3<sup>+</sup>PD-1<sup>+</sup> Cells to Tumor Cells: A More Accurate Predictor of Immunotherapy Outcomes in Advanced Non-Small-Cell Lung Cancer. [PDF]
Hu Z+12 more
europepmc +1 more source
MTV can greatly achieved antigen presenting cell (APCs), and THA will be released from the polyplex core and enhanced antigen presenting, thereby prompting APC maturation and antigen presenting. The membrane antigens on MTV are degraded into small peptides by proteasomes and presented by MHC complexes.
Anmin Huang+9 more
wiley +1 more source
<i>Trichinella spiralis</i>-derived extracellular vesicles induce regulatory T cells and reduce airway allergy in mice. [PDF]
Glamočlija S+9 more
europepmc +1 more source