Results 321 to 330 of about 160,147 (340)
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FOXP3+ regulatory T cells: control of FOXP3 expression by pharmacological agents
Trends in Pharmacological Sciences, 2011Naturally arising CD4(+)CD25(+) regulatory T cells (Tregs), which specifically express the forkhead family transcription factor FOXP3, are essential for the maintenance of immunological self-tolerance and immune homeostasis. Tregs can suppress the activation, proliferation and effector function of other lymphocytes in physiological and pathological ...
Naganari Ohkura +5 more
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FOXP3 and its partners: structural and biochemical insights into the regulation of FOXP3 activity
Immunologic Research, 2008Forkhead box protein P3 (FOXP3) contributes to a unique transcriptional signature and serves as a functional marker of CD4(+)CD25(+) natural regulatory T cells. Dysfunction of FOXP3 in human is associated with fatal autoimmune disease known as immunodysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) or X-linked autoimmunity ...
Bin Li +3 more
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Annual Review of Immunology, 2006
The immune system has evolved mechanisms to recognize and eliminate threats, as well as to protect against self-destruction. Tolerance to self-antigens is generated through two fundamental mechanisms: (a) elimination of self-reactive cells in the thymus during selection and (b) generation of a variety of peripheral regulatory cells to control self ...
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The immune system has evolved mechanisms to recognize and eliminate threats, as well as to protect against self-destruction. Tolerance to self-antigens is generated through two fundamental mechanisms: (a) elimination of self-reactive cells in the thymus during selection and (b) generation of a variety of peripheral regulatory cells to control self ...
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Nature Immunology, 2008
Inducible regulatory T cells respond to TGF-β by upregulating Foxp3 expression. Tone and colleagues identify an enhancer site in Foxp3 that binds transcription factors Smad3 and NFAT, suggesting a means by which TGF-β regulates Foxp3 expression.
Harald von Boehmer, Jens Nolting
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Inducible regulatory T cells respond to TGF-β by upregulating Foxp3 expression. Tone and colleagues identify an enhancer site in Foxp3 that binds transcription factors Smad3 and NFAT, suggesting a means by which TGF-β regulates Foxp3 expression.
Harald von Boehmer, Jens Nolting
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Nutrition, 2016
The aim of this study was to identify regulatory T cell (Treg) subsets residing in adipose tissue, demonstrate their immunosuppressive functions, and assess the possible role of Sirt1 in their function in overweight subjects.Fat samples were obtained by lipoaspiration from healthy overweight (n = 15) and normoweight (n = 11) subjects.
Juan D. Cortés-García +9 more
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The aim of this study was to identify regulatory T cell (Treg) subsets residing in adipose tissue, demonstrate their immunosuppressive functions, and assess the possible role of Sirt1 in their function in overweight subjects.Fat samples were obtained by lipoaspiration from healthy overweight (n = 15) and normoweight (n = 11) subjects.
Juan D. Cortés-García +9 more
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Suppression by human FOXP3 + regulatory T cells requires FOXP3-TIP60 interactions
Science Immunology, 2017Targeting the FOXP3-TIP60 interaction may modulate T reg activity in IPEX and other autoimmune and inflammatory diseases.
Khalid Bin Dhuban +16 more
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Nature Immunology, 2017
The histone lysine methyltransferase MLL4 primes the locus encoding the transcription factor Foxp3 for transcriptional activation in thymus-derived and inducible regulatory T cells.
Hai-Hui Xue, Dong-Mei Zhao
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The histone lysine methyltransferase MLL4 primes the locus encoding the transcription factor Foxp3 for transcriptional activation in thymus-derived and inducible regulatory T cells.
Hai-Hui Xue, Dong-Mei Zhao
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Human FOXP3 and tumour microenvironment
Immunology, 2022AbstractThe tumour microenvironment (TME) is a complex system composed of cancer cells, stromal cells and immune cells. Regulatory T cells (Tregs) in the TME impede immune surveillance of tumours and suppress antitumor immune responses. Transcription factor forkhead box protein 3 (FOXP3) is the main marker of Tregs, which dominates the function of ...
Jia Wang +5 more
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FOXP3 gene polymorphisms in preeclampsia
American Journal of Obstetrics and Gynecology, 2012To determine whether polymorphisms in the FOXP3 gene are associated with preeclampsia.Case-control study in which 120 women with preeclampsia were compared with 120 healthy normotensive controls. Genetic variants (single nucleotide polymorphisms and microsatellites) in the FOXP3 gene were analyzed.
Gregory J. Stoddard +3 more
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FOXP3 ensembles in T‐cell regulation
Immunological Reviews, 2006Summary: Our recent studies have identified dynamic protein ensembles containing forkhead box protein 3 (FOXP3) that provide insight into the molecular complexity of suppressor T‐cell activities, and it is our goal to determine how these ensembles regulate FOXP3's transcriptional activity in vivo. In this review, we summarize our current understanding
Kathryn T. Iacono +8 more
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