Results 331 to 340 of about 199,492 (387)

Brain metastasis in non‐small cell lung cancer: High‐risk factors and predictive models

VIEW, EarlyView.
Artificial intelligence (AI) can integrate of data to predict brain metastases (BM) in non‐small cell lung cancer (NSCLC). AI algorithms are employed to analyze these multifaceted datasets, enabling the identification of complex patterns and correlations that may not be apparent through traditional analytical methods.
Chen Gong, Ben Zhao, Shuangshuang Mao, Qingxu Liu, Yuanyuan Zhao, Yiwen Liu, Yao Luo, Qianxia Li   +7 more
wiley   +1 more source

Unlocking the therapeutic potential of thymus-isolated regulatory T cells. [PDF]

Front Immunol
Hu Y, Cruz H, Santosh Nirmala S, Fuchs A.   +3 more
europepmc   +1 more source

Age‐Related Oxidative Stress and Mitochondrial Dysfunction in Lymph Node Stromal Cells Limit the Peripheral T Cell Homeostatic Maintenance and Function

Aging Cell, EarlyView.
Aging of the lymph node stromal cells limits their ability to support the survival and maintenance of peripheral naive T cells. The lymph node stromal cells are critical for providing the survival and trophic signals to peripheral naïve T cells, and after the early‐life thymic involution, these secondary lymphoid organ stromal microniches are decisive ...
Sandip Ashok Sonar, Ruchika Bhat, Heather L. Thompson, Christopher P. Coplen, Jennifer L. Uhrlaub, Mladen Jergovic, Janko Ž. Nikolich   +6 more
wiley   +1 more source

Intranasal Application of Foxp3 Introduced with Poly(d,l-lactic-<i>co</i>-glycolic acid) (PLGA) Nanoparticles (Foxp3 NPs) Attenuates Allergic Inflammation in a Mouse Model of Allergic Rhinitis. [PDF]

Pharmaceutics
Han SC, Yeon S, Kim H, Park S.
europepmc   +1 more source

Multi‐Omics Analysis Reveals Biomarkers That Contribute to Biological Age Rejuvenation in Response to Single‐Blinded Randomized Placebo‐Controlled Therapeutic Plasma Exchange

Aging Cell, EarlyView.
Therapeutic plasma exchange safely reduces biological age by up to 2.6 years. Multi‐omics analysis reveals coordinated cellular and molecular responses associated with aging rejuvenation. ABSTRACT We conducted a randomized, placebo‐controlled trial to assess the safety and biological age (BA) effects of various therapeutic plasma exchange (TPE ...
Matias Fuentealba, Dobri Kiprov, Kevin Schneider, Wei‐Chieh Mu, Prasanna Ashok Kumaar, Herbert Kasler, Jordan B. Burton, Mark Watson, Heather Halaweh, Christina D. King, Zehra Stara Yüksel, Chelo Roska‐Pamaong, Birgit Schilling, Eric Verdin, David Furman   +14 more
wiley   +1 more source

Abnormal gut microbiota may cause PD-1 inhibitor-related cardiotoxicity via suppressing regulatory T cells. [PDF]

Sci Rep
Cao H, Dai H, Li S, Afzal Z, Wang X, Wen Z, Xiao K, Zhao Y, Li J, Yang B.   +9 more
europepmc   +1 more source

Aging Compromises Terminal Differentiation Program of Cytotoxic Effector Lineage and Promotes Exhaustion in CD8+ T Cells Responding to Coronavirus Infection

Aging Cell, EarlyView.
In a MHV infection model with age‐associated increased mortality, we demonstrate that aging impairs, instead of promoting, the terminal differentiation program of virus‐specific CD8+ T cells through downregulating key transcriptional regulators of terminal differentiation.
Ziang Zhu, Guohua Lou, Ying Luo, Kiddist Yihunie, Jonathan Hoar, Juan A. Daniel, Bret M. Evers, Chen Yao, Tuoqi Wu   +8 more
wiley   +1 more source

Study on the mechanism by which Xuanfu Hua Tang increases sensitivity of hepatocellular carcinoma cells to sorafenib by antagonizing the Notch1 pathway through HIF-2α. [PDF]

Front Oncol
Luo W, Li X, Shang Y, Chen Z, Cui Y.
europepmc   +1 more source

Single‐Cell Sequencing Reveals That CD4+ T Cells Eliminate Senescent Prostate Epithelium to Delay Progression of Benign Prostatic Hyperplasia

Aging Cell, EarlyView.
Senescent BPH epithelial cells secrete CXCL13 to recruit CD4+ T cells via CXCR5. Cytotoxic CD4+ T cells eliminate senescent cells through MHC‐II–dependent recognition. Tregs suppress, while B cells show minimal effect. This immune axis modulates senescent cell clearance and may influence BPH progression.
Zheng Li, Xiaofei Wang, Zhifu Liu, Senmao Li, Zhenan Zhang, Chenchen Huang, Yixiao Liu, Xingxing Tang, Jiaen Zhang, Peimin Zhou, Ying Gan, Yu Fan, Yisen Meng, Kaiwei Yang, Shuai Hu, Qian Zhang, Wei Yu   +16 more
wiley   +1 more source

Permissive immunosuppression facilitates the expansion of ex vivo administered regulatory T cells in the lung allograft. [PDF]

Sci Rep
Takahagi A, Miyamoto E, Lam C, Liu M, Joe B, Wang X, Hwang D, Martinu T, Cypel M, Keshavjee S, Juvet S.   +10 more
europepmc   +1 more source