Results 81 to 90 of about 517,707 (303)

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Fractional boundary value problems: Analysis and numerical methods [PDF]

open access: yes, 2011
This is the author's PDF of an article published in Fractional Calculus and Applied Analysis 2011. The original publication is available at www.springerlink.comThis journal article discusses nonlinear boundary value problems.Fundacao para a Ciencia e ...
M. Luísa Morgado   +3 more
core   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

open access: yesFEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi   +6 more
wiley   +1 more source

Antanas Matulevičius and his Petersburgs “Textbook of Arithmetic”

open access: yesLietuvos Matematikos Rinkinys, 2011
A. Matulevičius is one of the graduates of Veiveriai Teachers’ Seminary who became known for writing textbooks of mathematics in Lithuanian. His two-part “Textbook of Arithmetic” (Petersburg, 1916) was designed for teaching operations with numbers from ...
Juozas Banionis
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Fractional electrical impurity

open access: yesNew Journal of Physics
We examine the localized mode and the transmission of plane waves across a capacitive impurity of strength Δ, in a 1D bi-inductive electrical transmission line where the usual discrete Laplacian is replaced by a fractional one characterized by a ...
Mario I Molina
doaj   +1 more source

IMPROVING THE CHEMICAL PROPERTIES OF ACIDIC SOIL WITH AFFORDABLE LIME APPLICATION FOR INCREASING POTATO GROWTH AND YIELDS IN SEDIE DISTRICT, NORTHWESTERN ETHIOPIA [PDF]

open access: yesمجلة الأنبار للعلوم الزراعية
Soil acidity remains a critical issue in Ethiopia, particularly in the highland regions, where over 43% of arable lands has low pH levels. Enhancing the chemical properties of the soil and subsequent potato growth and yield through affordable lime ...
S. A. Yenesew
doaj   +1 more source

Fractional systems and fractional Bogoliubov hierarchy equations [PDF]

open access: yesPhysical Review E, 2005
We consider the fractional generalizations of the phase volume, volume element and Poisson brackets. These generalizations lead us to the fractional analog of the phase space. We consider systems on this fractional phase space and fractional analogs of the Hamilton equations. The fractional generalization of the average value is suggested.
openaire   +3 more sources

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

open access: yesFEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang   +4 more
wiley   +1 more source

Fractional location problems [PDF]

open access: yes
In this paper we analyze some variants of the classical uncapacitated facility location problem with a ratio as an objective function. Using basic concepts and results of fractional programming, we identify a class of one-level fractional location ...
Frenk, J.B.G.   +2 more
core  

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