Results 81 to 90 of about 20,179 (274)

The Variable-Order Fractional Calculus of Variations

, 2018
This book intends to deepen the study of the fractional calculus, giving special emphasis to variable-order operators. It is organized in two parts, as follows. In the first part, we review the basic concepts of fractional calculus (Chapter 1) and of the fractional calculus of variations (Chapter 2).
Almeida, Ricardo, Tavares, Dina, Torres, Delfim F. M.   +2 more
openaire   +2 more sources

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Beyond Chaos in Fractional-Order Systems: Keen Insight in the Dynamic Effects

Fractal and Fractional
Fractional calculus (or arbitrary order calculus) refers to the integration and derivative operators of an order different than one and was developed in 1695.
José Luis Echenausía-Monroy, Luis Alberto Quezada-Tellez, Hector Eduardo Gilardi-Velázquez, Omar Fernando Ruíz-Martínez, María del Carmen Heras-Sánchez, Jose E. Lozano-Rizk, José Ricardo Cuesta-García, Luis Alejandro Márquez-Martínez, Raúl Rivera-Rodríguez, Jonatan Pena Ramirez, Joaquín Álvarez   +10 more
doaj   +1 more source

Noether's Theorem for Fractional Optimal Control Problems

, 2006
We begin by reporting on some recent results of the authors (Frederico and Torres, 2006), concerning the use of the fractional Euler-Lagrange notion to prove a Noether-like theorem for the problems of the calculus of variations with fractional ...
Agrawal, Agrawal, Agrawal, Baleanu, El-Nabulsi, El-Nabulsi, Klimek, Klimek, Klimek, Klimek, Miller, Muslih, Riewe, Riewe, Samko, Torres, Torres   +16 more
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Analysis of Infection and Diffusion Coefficient in an SIR Model by Using Generalized Fractional Derivative

Fractal and Fractional
In this article, a diffusion component in an SIR model is introduced, and its impact is analyzed using fractional calculus. We have included the diffusion component in the SIR model. in order to illustrate the variations.
Ibtehal Alazman, Manvendra Narayan Mishra, Badr Saad Alkahtani, Ravi Shanker Dubey   +3 more
doaj   +1 more source

Central limit theorems for multiple Skorohod integrals [PDF]

, 2008
In this paper, we prove a central limit theorem for a sequence of iterated Shorohod integrals using the techniques of Malliavin calculus. The convergence is stable, and the limit is a conditionally Gaussian random variable. Some applications to sequences
Nourdin, Ivan, Nualart, David
core   +5 more sources

Discrete-Time Fractional Variational Problems

, 2010
We introduce a discrete-time fractional calculus of variations on the time scale $h\mathbb{Z}$, $h > 0$. First and second order necessary optimality conditions are established.
Bastos, Nuno R. O., Ferreira, Rui A. C., Torres, Delfim F. M.   +2 more
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source