Results 51 to 60 of about 857,826 (292)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Regression Coefficient Derivation via Fractional Calculus Framework
Journal of Mathematics, 2022 This study focuses on deriving coefficients of a simple linear regression model and a quadratic regression model using fractional calculus. The work has proven that there is a smooth connection between fractional operators and classical operators ...
Muath Awadalla +3 more
doaj +1 more source
A quaternionic perturbed fractional $ψ-$Fueter operator calculus
, 2021 arXiv admin note: substantial text overlap with arXiv:2109.09604; text overlap with arXiv:2111 ...
González-Cervantes, José Oscar +1 more
openaire +2 more sources
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Siago’s K-fractional calculus operators
Malaya Journal of Matematik, 2017 The aim of present paper is to define a pair of $k$-Saigo fractional integral and derivative operators involving generalized $k$-hypergeometric function. The Saigo-k generalized fractional operators involving $k$-hypergeometric function in the kernel are applied to the generalized $k$-Mittag-Leffler function and evaluate the formula$${ }_2 F_{1, k ...
null Anjali Gupta, null C.L. Parihar
openaire +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Fractional transformations of generalised functions [PDF]
, 2009 A distributional theory of fractional transformations is developed. A constructive approach, based on the eigenfunction expansion method pioneered by A. H.
Lamb, Wilson +2 more
core +3 more sources
Discrete fractional calculus with the nabla operator
Electronic Journal of Qualitative Theory of Differential Equations, 2009 Summary: Properties of discrete fractional calculus in the sense of a backward difference are introduced and developed. Exponential laws and a product rule are developed and relations to the forward fractional calculus are explored. Properties of the Laplace transform for the nabla derivative on the time scale of integers are developed and a fractional
Atici, Ferhan M., Eloe, Paul W.
openaire +2 more sources
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source