Results 61 to 70 of about 857,826 (292)

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

FEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan, Avi Singh, Shrawani Weralupe Gamladdalage, Joanna Hicks, Adele Williamson   +4 more
wiley   +1 more source

An Introductory Overview of Fractional-Calculus Operators Based Upon the Fox-Wright and Related Higher Transcendental Functions

Journal of Advanced Engineering and Computation, 2021
This survey-cum-expository review article is motivated essentially by the widespread usages of the operators of fractional calculus (that is, fractional-order integrals and fractional-order derivatives) in the modeling and analysis of a remarkably large ...
Hari Mohan Srivastava
doaj   +1 more source

Weighted Hardy-type inequalities involving fractional calculus operators [PDF]

, 2018
The aim of this paper is to give a new class of general weighted Hardy-type inequalities involving an arbitrary convex function with some applications of generalized fractional calculus convolutive operators which contain Gauss-hypergeometric function ...
Pečarić, Josip, Samraiz, Muhammad, Tomovski, Živorad, Iqbal, Sajid, Sajid Iqbal, Živorad Tomovski, Josip Pečarić, Muhammad Samraiz   +7 more
core   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Generalized proportional fractional integral Hermite–Hadamard’s inequalities

Advances in Difference Equations, 2021
The theory of fractional integral inequalities plays an intrinsic role in approximation theory also it has been a key in establishing the uniqueness of solutions for some fractional differential equations.
Tariq A. Aljaaidi, Deepak B. Pachpatte, Thabet Abdeljawad, Mohammed S. Abdo, Mohammed A. Almalahi, Saleh S. Redhwan   +5 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Mikusiński's operational calculus for an operator containing a fractional derivative

Revista Técnica de la Facultad de Ingeniería, 2011
The authors develop Mikusiński's operational calculus for the operator \(K_{\rho, \alpha} = t^{ - \alpha} D^{\rho - 1} t^ \alpha D\) with \(\rho > 1\) and \(\alpha > - 1\). Here \(D^{\rho-1}\) represents the Riemann-Liouville fractional calculus of order \(\rho-1\).
Jorge Betancor, Javier Barrios
openaire   +2 more sources