Results 71 to 80 of about 857,826 (292)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Mikusiński’s Operational Calculus for Fractional Operators with Different Kernels

IFAC-PapersOnLine
Mikusinski's operational calculus provides a way of applying the machinery of abstract algebra to the spaces and operators of calculus, thus allowing integro-differential equations to be solved by reducing them to algebraic equations. We summarise the application of this method to several operators of fractional calculus, defined by various ...
Fernandez, Arran, Rani, Noosheza
openaire   +2 more sources

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Pseudo-Quantum Fractional Calculus and Existence of Solutions for Delay Pseudo-Fractional Differential Equations in Generalized Banach Spaces

Journal of Mathematics
This paper presents a new framework of pseudo-q–fractional calculus in generalized Banach spaces by bringing together pseudo-analysis, G–calculus, and quantum calculus. We introduce Liouville–Caputo and Riemann–Liouville pseudo-q–fractional operators and
Alireza Hatami, Reza Saadati, Mohammad Bagher Ghaemi, Donal O’Regan   +3 more
doaj   +1 more source

Mikusinski’s Operational Calculus for Prabhakar Fractional Calculus

, 2023
Mikusinski operational calculus is a powerful yet underappreciated theory, enabling differential equations to be solved using abstract algebra. We realise the fractional integrals and derivatives of Prabhakar type within Mikusi´ nski’s theory, by defining them onnewfunction spaces and using their fundamental properties such as semigroup and series ...
openaire   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Images for the Y-Function via Marichev–Saigo–Maeda Fractional Integration and Differentiation Operators

International Journal of Mathematics and Mathematical Sciences
The Y-function has emerged as a significant tool in generalized fractional calculus due to its ability to unify and extend numerous classical special functions and hypergeometric-type functions.
Engdasew Birhane, D. L. Suthar
doaj   +1 more source

Application of Fractional-Order Differential Operators for Enhanced Electromagnetic Field Modeling in Electrical Devices and Electromechanical Systems

Energies
Accurate mapping of electromagnetic field distributions is crucial in the analysis and design of electromechanical devices such as electric machines. Fractional calculus is a tool currently under development that allows classical models to be generalized
Andrzej Zawadzki
doaj   +1 more source

Novel improved fractional operators and their scientific applications

Advances in Difference Equations, 2021
The motivation of this research is to introduce some new fractional operators called “the improved fractional (IF) operators”. The originality of these fractional operators comes from the fact that they repeat the method on general forms of conformable ...
Abd-Allah Hyder, M. A. Barakat
doaj   +1 more source

q-Fractional calculus for Rubin’s q-difference operator [PDF]

Advances in Difference Equations, 2013
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +2 more sources