Results 81 to 90 of about 980,464 (294)

Delivery of DNA‐encoded vaccines and proteins in mice using cutaneous suction‐mediated transfection

FEBS Open Bio, EarlyView.
Cutaneous suction‐mediated transfection in mice for delivery of DNA‐encoded vaccines and proteins. A critical limitation of DNA vaccines and other therapeutics is transfection in vivo to produce the encoded antigens or therapeutic proteins. Cutaneous suction‐based methods have demonstrated effectiveness in many animal models and have been successfully ...
Emran O. Lallow, Isabel Brandtjen, Yaxin Mo, Melissa Gulley, Louis Osorio, Sagar Kudchodkar, Nandita C. Jhumur, Christine C. Roberts, Lisa K. Denzin, David I. Shreiber, Biju Parekkadan, Hao Lin, Joel N. Maslow   +12 more
wiley   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

CO2 Laser Treatment of Multiple Oral Hamartomas in Cowden’s Syndrome: A Review and Case Study

Clinical, Cosmetic and Investigational Dermatology, 2022
Zoe Possick, Tina S Alster Washington Institute of Dermatologic Laser Surgery, Washington, DC, USACorrespondence: Tina S Alster, Washington Institute of Dermatologic Laser Surgery, 1430 K St, NW Suite 200, Washington, DC, 20005, USA, Tel +1 202 628-8855,
Possick Z, Alster TS
doaj  

Corrigendum to "Fractional release factors of long-lived halogenated organic compounds in the tropical stratosphere" published in Atmos. Chem. Phys., 10, 1093–1103, 2010 [PDF]

, 2010
We have noted a computational error in the calculation of the averaged Fractional Release Factors (FRFs) relative to the averaged FRF of CFCl3 (CFC-11). ..
T. Röckmann, J. C. Laube, Marine and Atmospheric Research, Röckmann, T., Laube, Johannes Christian, Engel, A., Bönisch, Harald, Bönisch, H., Sturges, W. T., Dep Natuurkunde, Braß, Marc, Röckmann, Thomas, Laube, J. C., Möbius, Tanja, W. T. Sturges, M. Braß, Sturges, William T., Engel, Andreas, H. Bönisch, A. Engel, Sub Atmospheric physics and chemistry, Braß, M., Möbius, T., T. Möbius, Leerstoel Taris   +24 more
core   +2 more sources

Identifying and characterising a plant GH1 β‐glucosidase that exhibits hydrolytic activity on N‐linked glucopyranoside

FEBS Open Bio, EarlyView.
We report the first β‐glucosidase with demonstrated hydrolytic activity on an N‐linked glycopyranoside. The enzyme, native to maize, was biochemically characterised for this novel reaction, and structural modelling of the enzyme–substrate complex revealed several clues to the underlying reduced catalytic rate relative to its native O‐glycopyranoside ...
Hani Gharabli, Carlotta Chiesa, Maher Abou Hachem, Ditte Hededam Welner   +3 more
wiley   +1 more source

Daily Emissions of CO2 in the World: A Fractional Integration Approach

Econometrics
In this article, daily CO2 emissions for the years 2019–2022 are examined using fractional integration for Brazil, China, EU-27 (and the UK), India, and the USA. According to the findings, all series exhibit long memory mean-reversion tendencies, with orders of integration ranging between 0.22 in the case of India (with white noise errors) and 0.70 for
Luis Alberiko Gil-Alana, Carlos Poza
openaire   +2 more sources

Fractional variational problems with the Riesz-Caputo derivative [PDF]

, 2012
In this paper we investigate optimality conditions for fractional variational problems, with a Lagrangian depending on the Riesz-Caputo derivative. First we prove a generalized Euler-Lagrange equation for the case when the interval of integration of the ...
Almeida, R., Ricardo Almeida
core   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

Pseudoxanthoma Elasticum Treatment with Fractional CO2 Laser

Plastic and Reconstructive Surgery Global Open, 2014
Pseudoxanthoma elasticum (PE) is a rare genetic disease characterized by calcification and fragmentation of elastic fibers of the skin, retina, and cardiovascular system. We report a case of PE in which fractional carbon dioxide laser treatment was successfully used to achieve improvement of the cervical skin with 2-year follow-up, in a patient with ...
Alessandra Grassi Salles, MD, PhD, Adelina Fátima do Nascimento Remigio, MD, Luciana Borsoi Moraes, MD, Andreza Cristina Camacho Varoni, MD, Rolf Gemperli, MD, PhD, Marcus Castro Ferreira, MD, PhD   +5 more
openaire   +3 more sources

Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells

FEBS Open Bio, EarlyView.
Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla, Martín M. Ledesma, Santiago A. Behr, Matías A. Pibuel, María L. Palanek, Daniel H. Grasso, Maria N. Garcia, Juan Garona, Silvina L. Lompardía, Elida Álvarez, Daniela L. Papademetrio   +10 more
wiley   +1 more source