Results 71 to 80 of about 42,207 (315)

New Approach for Fractional Order Derivatives: Fundamentals and Analytic Properties

open access: yesMathematics, 2016
The rate of change of any function versus its independent variables was defined as a derivative. The fundamentals of the derivative concept were constructed by Newton and l’Hôpital.
Ali Karcı
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

open access: yesFEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Fractional telegraph equation, Mittag-Leffler function, Hilfer derivative, Hadamard fractional derivative, Riesz-Feller space-fractional derivative

open access: yes, 2015
In this paper we consider space-time fractional telegraph equations, where the time derivatives are intended in the sense of Hilfer and Hadamard while the space fractional derivatives are meant in the sense of Riesz-Feller. We provide the Fourier transforms of the solutions of some Cauchy problems for these fractional equations.
Saxena, Ram K., Garra, R., Orsingher, E.
openaire   +2 more sources

Theory Analysis of Left-Handed Grünwald-Letnikov Formula with 0<α<1 to Detect and Locate Singularities

open access: yesAbstract and Applied Analysis, 2014
We study fractional-order derivatives of left-handed Grünwald-Letnikov formula with ...
Shaoxiang Hu, Ping Liang
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Description of Mechanical Movements Using Fractional Order Derivatives is not Objective [PDF]

open access: yesINCAS Bulletin, 2019
The papers deals with the objectivity in science. It aims at objectively describing the material particle movement and the movement of a continuum body.
Agneta M. BALINT, Stefan BALINT
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Fractional Systems with Multi-Parameters Fractional Derivatives

open access: yesInternational Journal of Theoretical Physics
Abstract Recently, a generalization of fractional variational formulations in terms of multiparameter fractional derivatives was introduced by Agrawal and Muslih. This treatment can be used to obtain the Lagrangian and Hamiltonian equations of motion.
Muslih, Sami I.   +2 more
openaire   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

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