Results 61 to 70 of about 2,428 (290)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
MathematicsAn initial value problem for a scalar nonlinear differential equation with a variable order for the generalized proportional Caputo fractional derivative is studied. We consider the case of a piecewise constant variable order of the fractional derivative.
Donal O’Regan +3 more
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Mathematics, 2021 We study the existence and multiplicity of positive solutions for a system of Riemann–Liouville fractional differential equations with sequential derivatives, positive parameters and sign-changing singular nonlinearities, subject to nonlocal coupled ...
Johnny Henderson +2 more
doaj +1 more source
Results on Katugampola Fractional Derivatives and Integrals
International Journal of Analysis and Applications, 2023 In this paper, we introduce and develop a new definitions for Katugampola derivative and Katugampola integral. In particular, we defined a (left) fractional derivative starting from a of a function f of order α∈(m-1, m] and a (right) fractional derivative terminating at b, where m ∈ N.
Iqbal H. Jebril +4 more
openaire +2 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Riesz potential operators and inverses via fractional centred derivatives
International Journal of Mathematics and Mathematical Sciences, 2006 Fractional centred differences and derivatives definitions are proposed, generalizing to real orders the existing ones valid for even and odd positive integer orders. For each one, suitable integral formulations are obtained.
Manuel Duarte Ortigueira
doaj +1 more source
Mathematics, 2019 In this paper, we establish three fundamental integral identities by the first- and second-order derivatives for a given function via the fractional integrals with exponential kernel.
Xia Wu, JinRong Wang, Jialu Zhang
doaj +1 more source
Fractional robust control of ligthly damped systems [PDF]
, 2006 The article proposes a method to design a robust controller ensuring the damping ratio of a closed-loop control. The method uses a contour para-meterized by the damping ratio in the Nichols plane and the complex non-integer (or fractional)differentiation
Janat, Yaman +3 more
core
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source