Results 81 to 90 of about 281,920 (272)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Hyers-Ulam Stability of Fractional Nabla Difference Equations [PDF]

International Journal of Analysis, 2016
We investigate the Hyers-Ulam stability, the generalized Hyers-Ulam stability, and the Fα-Hyers-Ulam stability of a linear fractional nabla difference equation using discrete Laplace transform. We provide a few examples to illustrate the applicability of established results.
openaire   +2 more sources

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Explicit Finite Difference Approximation for the TwoDimensional Fractional Dispersion Equation

Ibn Al-Haitham Journal for Pure and Applied Sciences, 2016
  In this paper, we introduce and discuss an algorithm for the numerical solution of two- dimensional fractional dispersion equation.  The algorithm for the numerical solution of this equation is based on explicit finite difference approximation ...
I. I. Gorial
doaj  

Discretization of Fractional Differential Equations by a Piecewise Constant Approximation

, 2016
There has recently been considerable interest in using a nonstandard piecewise approximation to formulate fractional order differential equations as difference equations that describe the same dynamical behaviour and are more amenable to a dynamical ...
Angstmann, Christopher N, Henry, Bruce I, McGann, Anna V   +2 more
core  

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Equivalent descriptions of a discrete-time fractional-order linear system and its stability domains

International Journal of Applied Mathematics and Computer Science, 2012
Two description forms of a linear fractional-order discrete system are considered. The first one is by a fractional-order difference equation, whereas the second by a fractional-order state-space equation.
Ostalczyk Piotr
doaj   +1 more source

Iterative positive solutions for fractional q-difference equations with p-Laplacian operator on infinite intervals [PDF]

Journal of Hebei University of Science and Technology
In order to enrich the basic theory of boundary value problems for fractional q-difference equations, the boundary value problems for a class of nonlinear fractional q-difference equations with p-Laplacian operator on infinite intervals were explored ...
Jufang WANG, Jinye ZHANG, Changlong YU
doaj   +1 more source

On the oscillation of q-fractional difference equations [PDF]

Advances in Difference Equations, 2017
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +3 more sources

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source