Results 61 to 70 of about 537,797 (362)

Disruption of SETD3‐mediated histidine‐73 methylation by the BWCFF‐associated β‐actin G74S mutation

FEBS Letters, EarlyView.
The β‐actin G74S mutation causes altered interaction of actin with SETD3, reducing histidine‐73 methylation efficiency and forming two distinct actin variants. The variable ratio of these variants across cell types and developmental stages contributes to tissue‐specific phenotypical changes. This imbalance may impair actin dynamics and mechanosensitive
Anja Marquardt, Marcus S. Münchhoff, Jacqueline Krohn, Philip M. Palarz, Manuel H. Taft, Johannes N. Greve, Nataliya Di Donato, Falk F. R. Buettner, Dietmar J. Manstein   +8 more
wiley   +1 more source

SEPARABLE LOCAL FRACTIONAL DIFFERENTIAL EQUATIONS [PDF]

Fractals, 2016
The concept of local fractional derivative was introduced in order to be able to study the local scaling behavior of functions. However it has turned out to be much more useful. It was found that simple equations involving these operators naturally incorporate the fractal sets into the equations.
openaire   +3 more sources

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

Molecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam, Megan E. Roche, Zhao Lin, Diana Whitaker‐Menezes, Victor Diaz‐Barros, Eurico Serrano, Maria Paula Martinez Cantarin, Nancy J. Philp, Atrayee Basu Mallick, Ubaldo Martinez‐Outschoorn   +9 more
wiley   +1 more source

Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM

Molecular Oncology, EarlyView.
CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak, Żaneta Zarębska, Marcin P. Sajek, Adriana Grabowska, Alessia Buratin, Paweł Głodowicz, Julia O. Misiorek, Konrad Kuczyński, Stefania Bortoluzzi, Marek Żywicki, Jan G. Kosiński, Agnieszka Rybak‐Wolf, Rafał Piestrzeniewicz, Anna M. Barciszewska, Katarzyna Rolle   +14 more
wiley   +1 more source

Lie symmetry analysis and conservation laws for the time fractional simplified modified Kawahara equation

Open Physics, 2018
In this work, Lie symmetry analysis for the time fractional simplified modified Kawahara (SMK) equation with Riemann-Liouville (RL) derivative, is analyzed.
Baleanu Dumitru, Inc Mustafa, Yusuf Abdullahi, Aliyu Aliyu Isa   +3 more
doaj   +1 more source

The G′G-expansion method using modified Riemann–Liouville derivative for some space-time fractional differential equations

Ain Shams Engineering Journal, 2014
In this paper, the fractional partial differential equations are defined by modified Riemann–Liouville fractional derivative. With the help of fractional derivative and traveling wave transformation, these equations can be converted into the nonlinear ...
Ahmet Bekir, Özkan Güner
doaj   +1 more source

On Solutions of Fractional order Telegraph Partial Differential Equation by Crank-Nicholson Finite Difference Method

Applied Mathematics and Nonlinear Sciences, 2020
The exact solution is calculated for fractional telegraph partial differential equation depend on initial boundary value problem. Stability estimates are obtained for this equation. Crank-Nicholson difference schemes are constructed for this problem. The
Mahmut Modanlı, Ali Akgül
semanticscholar   +1 more source

Neural fractional differential equations

Applied Mathematical Modelling
Fractional Differential Equations (FDEs) are essential tools for modelling complex systems in science and engineering. They extend the traditional concepts of differentiation and integration to non-integer orders, enabling a more precise representation of processes characterised by non-local and memory-dependent behaviours.
C. Coelho, M. Fernanda P. Costa, L.L. Ferrás   +2 more
openaire   +2 more sources

Mixed Collocation for Fractional Differential Equations

Numerical Algorithms, 2003
We present the mixed collocation method for numerical integration of fractional differential equations of the type D β u=Φ(u,t). Given a regular mesh with constant discretization step, the unknown u(t) is considered as continuous and affine in each cell, and the dynamics Φ(u,t) as a constant.
Dubois, François, Mengué, Stéphanie
openaire   +4 more sources

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source