Results 71 to 80 of about 10,103 (245)

Approximations for Fractional Derivatives and Fractional Integrals Using Padé Approximation

Journal of Applied Mathematics
This paper tackles the persistent challenge of slow convergence and numerical instability in the fractional calculus when applied to power series–representable functions fx=∑i=0∞cixi, limitations that compromise accuracy in scientific applications.
Ahmed M. Youssef, Tamer M. Rageh, Aisha F. Fareed, M. S. Abdelwahed   +3 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Long Run and Cyclical Dynamics in the US Stock Market [PDF]

This paper examines the long-run dynamics and the cyclical structure of various series related to the US stock market using fractional integration. We implement a procedure which enables one to consider unit roots with possibly fractional orders of ...
Luis A. Gil-Alana, Guglielmo Maria Caporale   +1 more
core  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Modelling Long-Run Trends and Cycles in Financial Time Series Data [PDF]

This paper proposes a very general time series framework to capture the long-run behaviour of financial series. The suggested model includes linear and non-linear time trends, and stationary and nonstationary processes based on integer and/or fractional ...
Luis A. Gil-Alana, Guglielmo Maria Caporale, Juncal Cunado   +2 more
core  

Chaos Analysis of the Fractional Genesio-Tesi System with Constant and Variable-Order Dynamics

Mathematics
Fractional calculus extends conventional differentiation and integration to non-integer orders, facilitating a more suitable modeling framework for complicated dynamical processes characterized by memory and long-range dependence.
Ghadah Alhawael, Mohamed A. Abdoon, Khaled Helmi Khashan, Diaa Eldin Elgezouli   +3 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Hybrid Shifted Gegenbauer Integral–Pseudospectral Method for Solving Time-Fractional Benjamin–Bona–Mahony–Burgers Equation

Mathematics
This paper introduces a novel hybrid shifted Gegenbauer integral–pseudospectral (HSG-IPS) method to solve the time-fractional Benjamin–Bona–Mahony–Burgers (FBBMB) equation with high accuracy.
Kareem T. Elgindy
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Fractional differentiation and its applications I - editorial

, 2013
Fractional calculus (FC) was originated from a genial idea of L’Hopital, who wrote Leibniz a letter dated September 30th, 1695, asking about a particular definition of the derivative of order n = 1/2.
Chen, Wen, Baleanu, Dumitru, Machado, J. A.Tenreiro   +2 more
core   +1 more source