Results 51 to 60 of about 8,551 (258)
Geometric and Physical Interpretation of Fractional Integration and Fractional Differentiation
, 2001 18 pages, 7 figures, 1 ...
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Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Novel improved fractional operators and their scientific applications
Advances in Difference Equations, 2021 The motivation of this research is to introduce some new fractional operators called “the improved fractional (IF) operators”. The originality of these fractional operators comes from the fact that they repeat the method on general forms of conformable ...
Abd-Allah Hyder, M. A. Barakat
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Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Fractional Integral Curves of Some Fractional Differential Equations
, 2022 International Journal of Electrical and Electronics Research, ISSN 2348-6988 (online), Research Publish Journals, Website: www.researchpublish ...
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Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
International Journal of Mathematics and Mathematical SciencesThe Y-function has emerged as a significant tool in generalized fractional calculus due to its ability to unify and extend numerous classical special functions and hypergeometric-type functions.
Engdasew Birhane, D. L. Suthar
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Modelling of the tumor growth under oncolytic virotherapy with piecewise differential operators: The effects of combinations of specialist viruses [PDF]
Mathematics and Computational SciencesThis study proposes to modify a mathematical model of virotherapy inducing cytokine IL-12 and co-stimulatory molecule 4-1BB ligand release with the concept of piecewise derivatives with the aim of analyzing the effects of treatment combinations on tumor ...
Seda Igret Araz, Elif Denk
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source