Results 61 to 70 of about 10,103 (245)

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Geometric and Physical Interpretation of Fractional Integration and Fractional Differentiation

, 2001
A solution to the more than 300-years old problem of geometric and physical interpretation of fractional integration and differentiation (i.e., integration and differentiation of an arbitrary real order) is suggested for the Riemann-Liouville fractional ...
Igor Podlubny
core  

Prediction of COVID-19 spread with models in different patterns: A case study of Russia

Open Physics
This study deals with a mathematical model that examines the spread of Coronavirus disease (COVID-19). This model has been handled with different processes such as deterministic, stochastic, and deterministic–stochastic. First of all, a detailed analysis
Cetin Mehmet Akif, Araz Seda Igret
doaj   +1 more source

Modelling of the tumor growth under oncolytic virotherapy with piecewise differential operators: The effects of combinations of specialist viruses [PDF]

Mathematics and Computational Sciences
This study proposes to modify a mathematical model of virotherapy inducing cytokine IL-12 and co-stimulatory molecule 4-1BB ligand release with the concept of piecewise derivatives with the aim of analyzing the effects of treatment combinations on tumor ...
Seda Igret Araz, Elif Denk
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

A Lucas Operational Matrix Method for Solving Nonlinear Fractional Two-Dimensional Partial Volterra Integral Equations

International Journal of Mathematics and Mathematical Sciences
This paper introduces a new numerical method for solving a class of two-dimensional fractional partial Volterra integral equations (2DFPVIEs). Our approach uses Lucas polynomials (LPs) to construct operational matrices (OMs) that effectively transform ...
S. S. Gholami, A. Ebadian, A. A. Khajehnasiri, Kareem T. Elgindy   +3 more
doaj   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Pseudo-Recursive Trapezoidal Rule for the Numerical Solution of Linear Fractional Differential Equations

, 2013
This paper presents an extension of the trapezoidal integration rule, that in the present work is applied to devise a pseudo-recursive numerical algorithm for the numerical evaluation of fractional-order integrals.
Rapaic M., PISANO, ALESSANDRO, GARRAPPA R, GARRAPPA, Roberto, Pisano A, Nessi D   +5 more
core   +1 more source