Results 61 to 70 of about 53,428 (260)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Wind power variations in time domain: Introducing a waiting time probabilistic distribution

Physics of Complex Systems
Time-dependent changes in wind speed (WS) observed at different locations in East Timor and Japan are analyzed using a statistical approach in the time domain.
Виталь де Жезус Шименес, Абелито Филипе Бело, Коити Симакава   +2 more
doaj   +1 more source

Special Fractional-Order Map and Its Realization

Mathematics, 2022
Recent works have focused the analysis of chaotic phenomena in fractional discrete memristor. However, most of the papers have been related to simulated results on the system dynamics rather than on their hardware implementations.
Amina-Aicha Khennaoui, Adel Ouannas, Shaher Momani, Othman Abdullah Almatroud, Mohammed Mossa Al-Sawalha, Salah Mahmoud Boulaaras, Viet-Thanh Pham   +6 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Fractional Integration and the Dynamics of UK Unemployment* [PDF]

Oxford Bulletin of Economics and Statistics, 2003
AbstractThis article is concerned with estimating the dynamic behaviour of UK unemployment using fractional integration methods. The question it considers is whether an unemployment model using a relatively small set of determinants of unemployment is consistent with the persistence which estimates an integrated model yield, or the much long‐lasting ...
Gil-Alaña, Luis A., Henry, Brian
openaire   +4 more sources

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Generalized Memory: Fractional Calculus Approach

Fractal and Fractional, 2018
The memory means an existence of output (response, endogenous variable) at the present time that depends on the history of the change of the input (impact, exogenous variable) on a finite (or infinite) time interval.
Vasily E. Tarasov
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Diffusion in Relatively Homogeneous Sand Columns: A Scale-Dependent or Scale-Independent Process?

Entropy, 2013
Solute transport through homogeneous media has long been assumed to be scale-independent and can be quantified by the second-order advection-dispersion equation (ADE). This study, however, observed the opposite in the laboratory, where transport of CuSO4
Jichun Wu, Xueyan Lv, Yong Zhang, Hongxia Xu   +3 more
doaj   +1 more source

Fractional Dynamics of Relativistic Particle [PDF]

International Journal of Theoretical Physics, 2009
Fractional dynamics of relativistic particle is discussed. Derivatives of fractional orders with respect to proper time describe long-term memory effects that correspond to intrinsic dissipative processes. Relativistic particle subjected to a non-potential four-force is considered as a nonholonomic system.
openaire   +2 more sources